1) Any situation where the solution cannot be carried out safely, 2) Allergic constitution, allergic to plasma or drugs, 3) Being too old with severe underlying diseases that affect survival, including uncontrolled clinically significant heart, lung, kidney, digestive, hematological, neuropsychiatric, immune, metabolic, or malignant tumors, Severe malnutrition, etc., 4) Patients with severe respiratory failure, heart failure, and multiple organ failure, 5) Participants in other clinical trials.

1) Any situation where the solution cannot be carried out safely, 2) Allergic constitution, allergic to plasma or drugs, 3) Being too old with severe underlying diseases that affect survival, including uncontrolled clinically significant heart, lung, kidney, digestive, hematological, neuropsychiatric, immune, metabolic, or malignant tumors, Severe malnutrition, etc., 4) Patients with severe respiratory failure, heart failure, and multiple organ failure, 5) Participants in other clinical trials.