1. History of tumor, 2. Vascular embolism and pulmonary hypertension, 3. Suspected or established history of alcohol, drug or drug abuse, 4. Female patients of child-bearing age who are pregnant, breast-feeding or have a recent family planning, 5. Patients who have participated in or are participating in other drug trials within one month, 6. Patients considered unfit to participate in this clinical trial.

1. History of tumor, 2. Vascular embolism and pulmonary hypertension, 3. Suspected or established history of alcohol, drug or drug abuse, 4. Female patients of child-bearing age who are pregnant, breast-feeding or have a recent family planning, 5. Patients who have participated in or are participating in other drug trials within one month, 6. Patients considered unfit to participate in this clinical trial.