1) Patients who may be transferred to other hospitals that are not included in the trial within 72 hours, 2) G-6PD defect (Favism), 3) Pregnancy, especially early pregnancy, 4) Patients who continually use immunosuppressant, or are organ transplant recipients within 6 months, 5) Hyperthyroidism, 6) Patients with medical ozone allergy, 7) Patients who are receiving other clinical trials.

1) Patients who may be transferred to other hospitals that are not included in the trial within 72 hours, 2) G-6PD defect (Favism), 3) Pregnancy, especially early pregnancy, 4) Patients who continually use immunosuppressant, or are organ transplant recipients within 6 months, 5) Hyperthyroidism, 6) Patients with medical ozone allergy, 7) Patients who are receiving other clinical trials.