1. Any situation which the protocol cannot be carried out safely, 2. Patient refuses to receive invasive tracheal support (if needed), 3. Pregnant or lactating women:childbearing age women with positive pregnancy test, breastfeeding, miscarriage or within 2 weeks after delivery.Postmenopausal and hysterectomy women do not need a pregnancy test, 4. Patients with chronic liver and kidney disease and reaching end-stage, 5. Previous history of allergic reactions to Fapiravir or Lopinavir and Ritonavir, 6. After the investigator's judgment, the subjects could not participate the study protocol, follow-up or self-evaluation after enrollment.

1. Any situation which the protocol cannot be carried out safely, 2. Patient refuses to receive invasive tracheal support (if needed), 3. Pregnant or lactating women:childbearing age women with positive pregnancy test, breastfeeding, miscarriage or within 2 weeks after delivery.Postmenopausal and hysterectomy women do not need a pregnancy test, 4. Patients with chronic liver and kidney disease and reaching end-stage, 5. Previous history of allergic reactions to Fapiravir or Lopinavir and Ritonavir, 6. After the investigator's judgment, the subjects could not participate the study protocol, follow-up or self-evaluation after enrollment.