1. Pregnant women, 2. Patients with a history of angina pectoris, myocardial infarction and other serious cardiovascular diseases, 3. The researchers judged that this study was not in the interests of patients.

1. Pregnant women, 2. Patients with a history of angina pectoris, myocardial infarction and other serious cardiovascular diseases, 3. The researchers judged that this study was not in the interests of patients.