1. Malignant disease in the past five years, 2. The clinical prediction is that there is no hope for survival, only cases of hospice care, or cases of deep coma that do not respond to supportive treatment measures within three hours of admission, 3. Subjects who are participating in other clinical trials or within 3 months, 4. Cases of very severe shock and respiratory failure.

1. Malignant disease in the past five years, 2. The clinical prediction is that there is no hope for survival, only cases of hospice care, or cases of deep coma that do not respond to supportive treatment measures within three hours of admission, 3. Subjects who are participating in other clinical trials or within 3 months, 4. Cases of very severe shock and respiratory failure.