1. Aged less than 18 years old, 2. Other serious medical diseases such as malignant tumor, heart, liver and kidney disease, uncontrollable metabolic disease, etc, 3. Not suitable for gastrointestinal administration, 4. Pregnant or lactating women, 5. Those who are allergic to the ingredients of this product, 6. Mental state can not cooperate with the observer or cognitive impairment, 7. Severe liver disease (such as child Pugh score >=C, AST > 5 times ULN), 8. Patients with known severe renal impairment (creatinine clearance rate <=30 ml/min) or continuous renal replacement therapy, hemodialysis, peritoneal dialysis.

1. Aged less than 18 years old, 2. Other serious medical diseases such as malignant tumor, heart, liver and kidney disease, uncontrollable metabolic disease, etc, 3. Not suitable for gastrointestinal administration, 4. Pregnant or lactating women, 5. Those who are allergic to the ingredients of this product, 6. Mental state can not cooperate with the observer or cognitive impairment, 7. Severe liver disease (such as child Pugh score >=C, AST > 5 times ULN), 8. Patients with known severe renal impairment (creatinine clearance rate <=30 ml/min) or continuous renal replacement therapy, hemodialysis, peritoneal dialysis.