Created at Source Raw Value Validated value
Oct. 26, 2020, 8:29 a.m. oms

1. Subjects have signed informed consent, agree not to participate in other clinical studies within 30 days from the first administration of the research drug to the last administration. 2. Aged >= 18 and <= 75 years. 3. Met the diagnostic criteria for COVID-19 (fifth edition, China). 4. SOFA score: 2 to 13 points. COVID-19 clinical stratifications: 1. Mild (n = 200): The clinical symptoms are mild or asymptomatic, and no pneumonia is seen on imaging, but the throat swab or mouthwash 2019-nCOV is positive. 2. General type (n = 160): with fever, respiratory tract symptoms, etc. Imaging shows pneumonia. 3. Severe type (n = 80): Meet any of the following criteria. (1) Respiratory distress, RR >= 30 times / minute. (2) In the resting state, the oxygen saturation is <= 93%. (3) Arterial blood oxygen partial pressure (PaO2) / oxygen concentration (FiO2) <= 300mmHg (1mmHg = 0.133kPa). 4. Critical type (n = 80): One of the following criteria: (1) Respiratory failure (ARDS) occurs and requires mechanical ventilation. (2) Shock. (3) Combined failure of other organs requires ICU monitoring and treatment.

1. Subjects have signed informed consent, agree not to participate in other clinical studies within 30 days from the first administration of the research drug to the last administration. 2. Aged >= 18 and <= 75 years. 3. Met the diagnostic criteria for COVID-19 (fifth edition, China). 4. SOFA score: 2 to 13 points. COVID-19 clinical stratifications: 1. Mild (n = 200): The clinical symptoms are mild or asymptomatic, and no pneumonia is seen on imaging, but the throat swab or mouthwash 2019-nCOV is positive. 2. General type (n = 160): with fever, respiratory tract symptoms, etc. Imaging shows pneumonia. 3. Severe type (n = 80): Meet any of the following criteria. (1) Respiratory distress, RR >= 30 times / minute. (2) In the resting state, the oxygen saturation is <= 93%. (3) Arterial blood oxygen partial pressure (PaO2) / oxygen concentration (FiO2) <= 300mmHg (1mmHg = 0.133kPa). 4. Critical type (n = 80): One of the following criteria: (1) Respiratory failure (ARDS) occurs and requires mechanical ventilation. (2) Shock. (3) Combined failure of other organs requires ICU monitoring and treatment.