1. Patients who have received immunotherapy (such as PD-1 / L1, CTLA4, etc.) and inflammatory factor modulators (such as Ulinastatin) within one month. 2. Patients who have used antibacterial drugs such as macrolides within one week. 3. Patients who have received other anti-2019-nCOV potentially effective drugs such as Lopinavir and Ritonavir within one week. 4. Those who have undergone organ transplantation or surgery planning within 6 months. 5. Patients with coma or intestinal obstruction can not eat or take medicine. 6. With severe illness affected survival, including uncontrolled malignant tumors that have been metastatic and can not be removed, blood diseases, cachexia, active bleeding, severe malnutrition, HIV, etc.. 7. Pregnant and lactating women, subjects (including male subjects) have a pregnancy plan (including sperm donation, egg donation plan) within the next 6 months or are unable to take effective contraceptive measures. 8. Patients with allergies or allergies to macrolide drugs, lopinavir / ritonavir tablets. 9. Patients with contraindications to using lopinavir / ritonavir tablets who plan or are using drugs that interact with the drug (including: highly dependent on CYP3A clearance and increased plasma concentrations can be severe and / or Life-threatening events [narrow therapeutic index] drugs, CYP3A inducers [see the instructions for details]), and can not be stopped or switched to other drugs. 10. Elevated alanine aminotransferase (ALT) / glutaminase (AST) is more than five times the upper limit of normal, total bilirubin is three times the upper limit of normal, or child-Pugh grade C cirrhosis. 11. Extracorporeal life support (ECMO, ECCO2R, RRT). 12. Critical patients with an estimated survival time of < 48 h. 13. Participants in other clinical research in the past month. 14. At the investigator's discretion, patients were deemed unsuitable for inclusion.

1. Patients who have received immunotherapy (such as PD-1 / L1, CTLA4, etc.) and inflammatory factor modulators (such as Ulinastatin) within one month. 2. Patients who have used antibacterial drugs such as macrolides within one week. 3. Patients who have received other anti-2019-nCOV potentially effective drugs such as Lopinavir and Ritonavir within one week. 4. Those who have undergone organ transplantation or surgery planning within 6 months. 5. Patients with coma or intestinal obstruction can not eat or take medicine. 6. With severe illness affected survival, including uncontrolled malignant tumors that have been metastatic and can not be removed, blood diseases, cachexia, active bleeding, severe malnutrition, HIV, etc.. 7. Pregnant and lactating women, subjects (including male subjects) have a pregnancy plan (including sperm donation, egg donation plan) within the next 6 months or are unable to take effective contraceptive measures. 8. Patients with allergies or allergies to macrolide drugs, lopinavir / ritonavir tablets. 9. Patients with contraindications to using lopinavir / ritonavir tablets who plan or are using drugs that interact with the drug (including: highly dependent on CYP3A clearance and increased plasma concentrations can be severe and / or Life-threatening events [narrow therapeutic index] drugs, CYP3A inducers [see the instructions for details]), and can not be stopped or switched to other drugs. 10. Elevated alanine aminotransferase (ALT) / glutaminase (AST) is more than five times the upper limit of normal, total bilirubin is three times the upper limit of normal, or child-Pugh grade C cirrhosis. 11. Extracorporeal life support (ECMO, ECCO2R, RRT). 12. Critical patients with an estimated survival time of < 48 h. 13. Participants in other clinical research in the past month. 14. At the investigator's discretion, patients were deemed unsuitable for inclusion.