1. Involving in other drug clinical trial, 2. Pregnant or breastfeeding, 3. Presence of other serious diseases that may be life threatening, such as cancer, 4. Expected life is less than 24 hours, 5. Allergy to ALA or drugs of similar chemical classes (Vitamin B),previous history of intolerance to recommended target doses of alpha-LA, 6. diagnosed with diseases of immune system.

1. Involving in other drug clinical trial, 2. Pregnant or breastfeeding, 3. Presence of other serious diseases that may be life threatening, such as cancer, 4. Expected life is less than 24 hours, 5. Allergy to ALA or drugs of similar chemical classes (Vitamin B),previous history of intolerance to recommended target doses of alpha-LA, 6. diagnosed with diseases of immune system.