Created at Source Raw Value Validated value
Oct. 26, 2020, 8:29 a.m. oms

1. The physician decides that participating in the trial is not in the best interest of the patient, or does not meet any conditions for safe follow-up in the protocol, 2. People with heart disease such as cardiac block, 3. People with eye diseases such as retina and cornea, 4. Severe liver disease (such as Child Pugh score >= C or AST > 5 times the upper limit), 5. Pregnancy or breastfeeding, or a positive pregnancy test during the pre-dose check, 6. Patients with known severe renal insufficiency (estimated glomerular filtration rate <= 30mL / min / 1.73m2) or receiving continuous renal replacement therapy, hemodialysis, peritoneal dialysis.

1. The physician decides that participating in the trial is not in the best interest of the patient, or does not meet any conditions for safe follow-up in the protocol, 2. People with heart disease such as cardiac block, 3. People with eye diseases such as retina and cornea, 4. Severe liver disease (such as Child Pugh score >= C or AST > 5 times the upper limit), 5. Pregnancy or breastfeeding, or a positive pregnancy test during the pre-dose check, 6. Patients with known severe renal insufficiency (estimated glomerular filtration rate <= 30mL / min / 1.73m2) or receiving continuous renal replacement therapy, hemodialysis, peritoneal dialysis.