age \< 18 pregnant allergic to experimental drugs and patients have the following conditions: 1. hypercholesterolemia 2. hypertriglyceridemia 3. liver disease 4. renal disease 5. sjögren syndrome 6. pregnancy 7. lactation 8. depressive disorder 9. body mass index less than 18 points or higher than 25 points 10. contraindications for hormonal contraception or intrauterine device. 11. autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation 12. patients receiving anti-hcv treatment 13. permanent blindness in one eye 14. history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery 15. the competent physician considered it inappropriate to participate in the study 16. bleeding dyscrasia 16-1-anti-coagulation use active cervicitis 17. allergy to tamoxifen 18. history of venous thromboembolism 19. personal history of breast or uterine malignancy 20. use of medication contraindicated with use of tamoxifen (coumadin, letrozole, bromocriptine, rifampicin, aminoglutethimide, phenobarbital)

age \< 18 pregnant allergic to experimental drugs and patients have the following conditions: 1. hypercholesterolemia 2. hypertriglyceridemia 3. liver disease 4. renal disease 5. sjögren syndrome 6. pregnancy 7. lactation 8. depressive disorder 9. body mass index less than 18 points or higher than 25 points 10. contraindications for hormonal contraception or intrauterine device. 11. autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation 12. patients receiving anti-hcv treatment 13. permanent blindness in one eye 14. history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery 15. the competent physician considered it inappropriate to participate in the study 16. bleeding dyscrasia 16-1-anti-coagulation use active cervicitis 17. allergy to tamoxifen 18. history of venous thromboembolism 19. personal history of breast or uterine malignancy 20. use of medication contraindicated with use of tamoxifen (coumadin, letrozole, bromocriptine, rifampicin, aminoglutethimide, phenobarbital)

age < 18 pregnant allergic to experimental drugs and patients have the following conditions: hypercholesterolemia hypertriglyceridemia liver disease renal disease sjögren syndrome pregnancy lactation depressive disorder body mass index less than 18 points or higher than 25 points contraindications for hormonal contraception or intrauterine device. autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation patients receiving anti-hcv treatment permanent blindness in one eye history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery the competent physician considered it inappropriate to participate in the study bleeding dyscrasia 16-1-anti-coagulation use active cervicitis allergy to tamoxifen history of venous thromboembolism personal history of breast or uterine malignancy use of medication contraindicated with use of tamoxifen (coumadin, letrozole, bromocriptine, rifampicin, aminoglutethimide, phenobarbital)

age < 18 pregnant allergic to experimental drugs and patients have the following conditions: hypercholesterolemia hypertriglyceridemia liver disease renal disease sjögren syndrome pregnancy lactation depressive disorder body mass index less than 18 points or higher than 25 points contraindications for hormonal contraception or intrauterine device. autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation patients receiving anti-hcv treatment permanent blindness in one eye history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery the competent physician considered it inappropriate to participate in the study bleeding dyscrasia 16-1-anti-coagulation use active cervicitis allergy to tamoxifen history of venous thromboembolism personal history of breast or uterine malignancy use of medication contraindicated with use of tamoxifen (coumadin, letrozole, bromocriptine, rifampicin, aminoglutethimide, phenobarbital)

age < 18 pregnant allergic to experimental drugs and patients have the following conditions: 1. hypercholesterolemia 2. hypertriglyceridemia 3. liver disease 4. renal disease 5. sjögren syndrome 6. pregnancy 7. lactation 8. depressive disorder 9. body mass index less than 18 points or higher than 25 points 10. contraindications for hormonal contraception or intrauterine device. 11. autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation 12. patients receiving anti-hcv treatment 13. permanent blindness in one eye 14. history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery 15. the competent physician considered it inappropriate to participate in the study 16. bleeding dyscrasia 16-1-anti-coagulation use active cervicitis 17. allergy to tamoxifen 18. history of venous thromboembolism 19. personal history of breast or uterine malignancy 20. use of medication contraindicated with use of tamoxifen (coumadin, letrozole, bromocriptine, rifampicin, aminoglutethimide, phenobarbital)

age < 18 pregnant allergic to experimental drugs and patients have the following conditions: 1. hypercholesterolemia 2. hypertriglyceridemia 3. liver disease 4. renal disease 5. sjögren syndrome 6. pregnancy 7. lactation 8. depressive disorder 9. body mass index less than 18 points or higher than 25 points 10. contraindications for hormonal contraception or intrauterine device. 11. autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation 12. patients receiving anti-hcv treatment 13. permanent blindness in one eye 14. history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery 15. the competent physician considered it inappropriate to participate in the study 16. bleeding dyscrasia 16-1-anti-coagulation use active cervicitis 17. allergy to tamoxifen 18. history of venous thromboembolism 19. personal history of breast or uterine malignancy 20. use of medication contraindicated with use of tamoxifen (coumadin, letrozole, bromocriptine, rifampicin, aminoglutethimide, phenobarbital)