1. Pregnant or lactating women, or pregnant, 2. Those who are allergic to the drug ingredients of this program, 3. Severe cardiovascular diseases, such as severe center of gravity dysfunction, second or third degree atrioventricular block, etc., 4. Severe hepatic insufficiency: defined as the upper limit of ALT > 2 times normal value or AST > 2 times normal value, 5. Severe renal insufficiency: defined as creatinine > 1.5 times the upper limit of normal value, 6. Have asthma, COPD serious respiratory disease, 7. Serious blood diseases, such as coagulation disorders, systemic bleeding, platelet diseases, etc, 8. Serious endocrine system diseases, such as type II diabetes, 9. Patients with malignant tumor, 10. Patients taking antiedematous drugs for a long time, 11. Major operation history, 12. Other clinical researchers.

1. Pregnant or lactating women, or pregnant, 2. Those who are allergic to the drug ingredients of this program, 3. Severe cardiovascular diseases, such as severe center of gravity dysfunction, second or third degree atrioventricular block, etc., 4. Severe hepatic insufficiency: defined as the upper limit of ALT > 2 times normal value or AST > 2 times normal value, 5. Severe renal insufficiency: defined as creatinine > 1.5 times the upper limit of normal value, 6. Have asthma, COPD serious respiratory disease, 7. Serious blood diseases, such as coagulation disorders, systemic bleeding, platelet diseases, etc, 8. Serious endocrine system diseases, such as type II diabetes, 9. Patients with malignant tumor, 10. Patients taking antiedematous drugs for a long time, 11. Major operation history, 12. Other clinical researchers.