Patients who is enrolled in other clinical trial who had diagnosed as macular degeneration of retinawere or defects of visual field, who was allergic to 4-aminoquinoline compounds or is prescribed any drug had interactions with hydrocholoroquine emergency or critically ill patients who can not received oral drugs pregnancy or lactation severe heart disease, digestive disease,neurological or ocular disease,or porphyrin, WBC less than 2.0*10^9/L,hemoglobin 60g/L,liver enzyme or creatine higher than 3 times of ULT,or heart marker elevated, unsuitable to participate this trial by investigator or in other special circumstances.

Patients who is enrolled in other clinical trial who had diagnosed as macular degeneration of retinawere or defects of visual field, who was allergic to 4-aminoquinoline compounds or is prescribed any drug had interactions with hydrocholoroquine emergency or critically ill patients who can not received oral drugs pregnancy or lactation severe heart disease, digestive disease,neurological or ocular disease,or porphyrin, WBC less than 2.0*10^9/L,hemoglobin 60g/L,liver enzyme or creatine higher than 3 times of ULT,or heart marker elevated, unsuitable to participate this trial by investigator or in other special circumstances.