Subjects participating in this clinical study must meet all of the following criteria: 1. General- severe hospitalized patients who meet the diagnostic criteria of the New Coronavirus Infected Pneumonia Diagnosis and Treatment Plan (Trial Version 5) . That is, one of the following three conditions is met on the premise that the general diagnostic criteria are met: 1) Respiratory frequency (RR): 20-30 times / minute, 2) Peripheral oxygen saturation: 93-95%, 3) Arterial blood oxygen partial pressure (PaO2) / oxygen concentration (FiO2): 300-400mmHg (1mmHg = 0.133kPa). 2. Patients aged >= 18 and <= 85 years, with normal autonomous judgment ability, regardless of gender and region, 3. Patients who voluntarily participated in the study and signed informed consent.

Subjects participating in this clinical study must meet all of the following criteria: 1. General- severe hospitalized patients who meet the diagnostic criteria of the New Coronavirus Infected Pneumonia Diagnosis and Treatment Plan (Trial Version 5) . That is, one of the following three conditions is met on the premise that the general diagnostic criteria are met: 1) Respiratory frequency (RR): 20-30 times / minute, 2) Peripheral oxygen saturation: 93-95%, 3) Arterial blood oxygen partial pressure (PaO2) / oxygen concentration (FiO2): 300-400mmHg (1mmHg = 0.133kPa). 2. Patients aged >= 18 and <= 85 years, with normal autonomous judgment ability, regardless of gender and region, 3. Patients who voluntarily participated in the study and signed informed consent.