1. Adults (defined as age >= 18 years), 2. Patients with new type of coronavirus infection confirmed by PCR / serum antibodies, 3. The time interval between symptom onset and random enrollment is within 10 days.The onset of symptoms is mainly based on fever. If there is no fever, cough or other related symptoms can be used, 4. Imaging confirmed pneumonia, 5. In the state of no oxygen at rest, the patient's blood oxygen saturation SPO2 <= 94% or shortness of breath (breathing frequency >= 24) or oxygenation index <= 300mmHg.

1. Adults (defined as age >= 18 years), 2. Patients with new type of coronavirus infection confirmed by PCR / serum antibodies, 3. The time interval between symptom onset and random enrollment is within 10 days.The onset of symptoms is mainly based on fever. If there is no fever, cough or other related symptoms can be used, 4. Imaging confirmed pneumonia, 5. In the state of no oxygen at rest, the patient's blood oxygen saturation SPO2 <= 94% or shortness of breath (breathing frequency >= 24) or oxygenation index <= 300mmHg.