1. Patients with other malignant tumors requiring treatment, 2. Severe cardiovascular and metabolic diseases beyond the control of combination with other drugs 3. Patients with clinical symptoms of brain dysfunction or serious mental illness who cannot understand or follow the study protocol, 4. Endotracheal intubation with invasive ventilation, 5. Patients who cannot guarantee completion of necessary treatment plan and follow-up observation, 6. Women of child-bearing age who are positive in pregnancy test or do not stop breastfeeding in lactation period, 7. Patients with other infections at the time of enrollment, 8. Other circumstances that prevent the protocol from proceeding safely.

1. Patients with other malignant tumors requiring treatment, 2. Severe cardiovascular and metabolic diseases beyond the control of combination with other drugs 3. Patients with clinical symptoms of brain dysfunction or serious mental illness who cannot understand or follow the study protocol, 4. Endotracheal intubation with invasive ventilation, 5. Patients who cannot guarantee completion of necessary treatment plan and follow-up observation, 6. Women of child-bearing age who are positive in pregnancy test or do not stop breastfeeding in lactation period, 7. Patients with other infections at the time of enrollment, 8. Other circumstances that prevent the protocol from proceeding safely.