1. Hypersensitive to study drug, 2. Body weight <40 kg, 3. Considered as severe disease: has an ongoing respiratory deficiency and subjected to invasive mechanical ventilation, or presence of shock, or admitted to the ICU due to complications, 4. Has known kidney dysfunction determined as CLcr<60 mL/min, 5. Increase in alanine aminotransferase (ALT) / aspartate aminotransferase (AST) is more than 5 times the upper limit of normal, or increase in ALT or AST is more than 3 ULN and increase in total bilirubin more than 2 ULN, 6. Pregnancy or breastfeeding,or positive pregnancy test in a predose examination, or have a plan to be pregnant within 3 months after the study.

1. Hypersensitive to study drug, 2. Body weight <40 kg, 3. Considered as severe disease: has an ongoing respiratory deficiency and subjected to invasive mechanical ventilation, or presence of shock, or admitted to the ICU due to complications, 4. Has known kidney dysfunction determined as CLcr<60 mL/min, 5. Increase in alanine aminotransferase (ALT) / aspartate aminotransferase (AST) is more than 5 times the upper limit of normal, or increase in ALT or AST is more than 3 ULN and increase in total bilirubin more than 2 ULN, 6. Pregnancy or breastfeeding,or positive pregnancy test in a predose examination, or have a plan to be pregnant within 3 months after the study.