1. Allergic history to study medicines, 2. ALT/AST >5 UNL or Child-Pugh Class C, 3. Severely ill patients with life expectance <48 hours, 4. Contraindication of DRV or thymosin, 5. Pregnancy testing positive for child-bearing woman, 6. Known HIV infection, 7. not adequate to be enrolled.

1. Allergic history to study medicines, 2. ALT/AST >5 UNL or Child-Pugh Class C, 3. Severely ill patients with life expectance <48 hours, 4. Contraindication of DRV or thymosin, 5. Pregnancy testing positive for child-bearing woman, 6. Known HIV infection, 7. not adequate to be enrolled.