1. Patients with serious illnesses, such as heart, liver, kidney, endocrine diseases and hematopoietic system disease, 2. Pregnant or lactating women, 3. Patients who have mental confusion, who with a history of drug abuse or dependence, who allergic to study medication, who have participated in another clinical trial within 3 months,or who have other conditions not suitable for clinical study.

1. Patients with serious illnesses, such as heart, liver, kidney, endocrine diseases and hematopoietic system disease, 2. Pregnant or lactating women, 3. Patients who have mental confusion, who with a history of drug abuse or dependence, who allergic to study medication, who have participated in another clinical trial within 3 months,or who have other conditions not suitable for clinical study.