1. Those with allergies, 2. Patients with a history of severe cardio-cerebral vascular disease, diabetes, mental and neurological diseases, severe liver and renal insufficiency, 3. History of hip or knee trauma or surgery, 4. Patients who abuse drugs, 5. Those who are in the acute phase of chronic diseases, 6. Patients with other malignant diseases and a survival time of less than 12 months, 7. pregnancy,lactating women, 8. Poor compliance and unable to follow up on time, 9. Participants in clinical trials of other drugs or devices within the past 3 months.

1. Those with allergies, 2. Patients with a history of severe cardio-cerebral vascular disease, diabetes, mental and neurological diseases, severe liver and renal insufficiency, 3. History of hip or knee trauma or surgery, 4. Patients who abuse drugs, 5. Those who are in the acute phase of chronic diseases, 6. Patients with other malignant diseases and a survival time of less than 12 months, 7. pregnancy,lactating women, 8. Poor compliance and unable to follow up on time, 9. Participants in clinical trials of other drugs or devices within the past 3 months.