(1) Patients are diagnosed as a case of severe NCIP, (2) Patients are pregnant or breastfeeding women, (3) Patients have aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 5×UNL or creatinine clearance <50 ml / min, (4) Patients are allergic or intolerant to the proposed antiviral therapeutic drugs, (5) Patients are HIV-positive, (6) Patients with hemoglobin disease (7) Patients have severe heart disease, brain disease, lung disease, kidney disease, tumor or other severe systemic diseases, (8) Patients are not willing to provide signed informed consent.

(1) Patients are diagnosed as a case of severe NCIP, (2) Patients are pregnant or breastfeeding women, (3) Patients have aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 5×UNL or creatinine clearance <50 ml / min, (4) Patients are allergic or intolerant to the proposed antiviral therapeutic drugs, (5) Patients are HIV-positive, (6) Patients with hemoglobin disease (7) Patients have severe heart disease, brain disease, lung disease, kidney disease, tumor or other severe systemic diseases, (8) Patients are not willing to provide signed informed consent.