1. Male or female over 18 years of age, 2. Novel coronavirus infection is confirmed by pathogenic detection, 3. The diagnosis of severe coronavirus pneumonia will have to meet at least one of the following criteria: (1) Respiratory distress, RR>30 times/minute (2) In the state of no oxygen at rest, the patient's SPO2<=93% (3) Oxygenation Index (PaO2/FiO2)<=300 mmHg (1mmHg=0.133kPa), (4) Respiratory failure requiring mechanical ventilation, (5) Sepsis, (6) Other organ failure requiring ICU care. 4. Be willing to give the informed consent.

1. Male or female over 18 years of age, 2. Novel coronavirus infection is confirmed by pathogenic detection, 3. The diagnosis of severe coronavirus pneumonia will have to meet at least one of the following criteria: (1) Respiratory distress, RR>30 times/minute (2) In the state of no oxygen at rest, the patient's SPO2<=93% (3) Oxygenation Index (PaO2/FiO2)<=300 mmHg (1mmHg=0.133kPa), (4) Respiratory failure requiring mechanical ventilation, (5) Sepsis, (6) Other organ failure requiring ICU care. 4. Be willing to give the informed consent.