* patients must not be pregnant or nursing * patients cannot be admitted to intensive care unit at time of admission or require positive pressure ventilation * patients cannot be requiring continuous supplemental oxygen normally (pre-sars-cov-2) * patient is receiving steroids \>1mg/kg * has diagnosis of primary immunodeficiency * has active autoimmune disease that has required systemic treatment in the past year * has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial * patients with ferritin \>2000ng/ml and/or c-reactive protein \>100mg/l * history of allogeneic hematopoietic cell transplantation or solid organ transplantation * childs-pugh class b or c cirrhosis or class a if portal hypertension is present * documented allergic or hypersensitivity response to protein therapeutics * no serious disease requiring mechanical ventilation at time of enrollment

* patients must not be pregnant or nursing * patients cannot be admitted to intensive care unit at time of admission or require positive pressure ventilation * patients cannot be requiring continuous supplemental oxygen normally (pre-sars-cov-2) * patient is receiving steroids \>1mg/kg * has diagnosis of primary immunodeficiency * has active autoimmune disease that has required systemic treatment in the past year * has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial * patients with ferritin \>2000ng/ml and/or c-reactive protein \>100mg/l * history of allogeneic hematopoietic cell transplantation or solid organ transplantation * childs-pugh class b or c cirrhosis or class a if portal hypertension is present * documented allergic or hypersensitivity response to protein therapeutics * no serious disease requiring mechanical ventilation at time of enrollment

- patients must not be pregnant or nursing - patients cannot be admitted to intensive care unit at time of admission or require positive pressure ventilation - patients cannot be requiring continuous supplemental oxygen normally (pre-sars-cov-2) - patient is receiving steroids >1mg/kg - has diagnosis of primary immunodeficiency - has active autoimmune disease that has required systemic treatment in the past year - has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial - patients with ferritin >2000ng/ml and/or c-reactive protein >100mg/l - history of allogeneic hematopoietic cell transplantation or solid organ transplantation - childs-pugh class b or c cirrhosis or class a if portal hypertension is present - documented allergic or hypersensitivity response to protein therapeutics - no serious disease requiring mechanical ventilation at time of enrollment

- patients must not be pregnant or nursing - patients cannot be admitted to intensive care unit at time of admission or require positive pressure ventilation - patients cannot be requiring continuous supplemental oxygen normally (pre-sars-cov-2) - patient is receiving steroids >1mg/kg - has diagnosis of primary immunodeficiency - has active autoimmune disease that has required systemic treatment in the past year - has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial - patients with ferritin >2000ng/ml and/or c-reactive protein >100mg/l - history of allogeneic hematopoietic cell transplantation or solid organ transplantation - childs-pugh class b or c cirrhosis or class a if portal hypertension is present - documented allergic or hypersensitivity response to protein therapeutics - no serious disease requiring mechanical ventilation at time of enrollment