Created at Source Raw Value Validated value
Oct. 26, 2020, 8:29 a.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "ARM 3 - Moderate COVID-19 infectionDrug: SelinexorDose: 20mg 3x weeklyDuration: 14 daysMode: oral - self administered tabletadherence: supervised administration while inpatient. self reported.Description of study design:This SMART design specifies that participants entering the trial who have had no known COVID-19 exposure are initially randomised to either low-dose intranasal IFN-a or placebo as pre-exposure prophylaxis against developing COVID-19. Any participants who have a known COVID-19 exposure are randomised to high-dose IFN-a or placebo as a post-exposure prophylaxis against developing COVID-19. If; at any stage after enrolling; a participant develops \u2018moderate\u2019 COVID-19; then they are then randomised to either selinexor or placebo; and if at any stage after enrolling the participant develops \u2018severe\u2019 COVID-19 they are then randomised to either lenzilumab or placebo.Importantly; participants enrolling into the trial can directly enter any of the four interventions if they meet the appropriate entry criteria.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}, {"arm_notes": "", "treatment_id": 1182, "treatment_name": "Selinexor", "treatment_type": "Others pharmacological treatment", "pharmacological_treatment": "Pharmacological treatment"}]