* exclusion criteria were pregnancy, g6phd (glucose 6 phosphate dehydrogenase) deficiency, concomitant serious disease and failure to obtain informed consent.

* exclusion criteria were pregnancy, g6phd (glucose 6 phosphate dehydrogenase) deficiency, concomitant serious disease and failure to obtain informed consent.

- exclusion criteria were pregnancy, g6phd (glucose 6 phosphate dehydrogenase) deficiency, concomitant serious disease and failure to obtain informed consent.

- exclusion criteria were pregnancy, g6phd (glucose 6 phosphate dehydrogenase) deficiency, concomitant serious disease and failure to obtain informed consent.