1. history of allergic reactions to blood products 2. sofa scale \>12 points 3. absolute contraindication for administration of plasma 4. participation in other blinded clinical trial 5. projected life expectancy less than 3 months 6. any condition perceived by the investigator as not appropriate for participation of the patient in the trial.

1. history of allergic reactions to blood products 2. sofa scale \>12 points 3. absolute contraindication for administration of plasma 4. participation in other blinded clinical trial 5. projected life expectancy less than 3 months 6. any condition perceived by the investigator as not appropriate for participation of the patient in the trial.

history of allergic reactions to blood products sofa scale >12 points absolute contraindication for administration of plasma participation in other blinded clinical trial projected life expectancy less than 3 months any condition perceived by the investigator as not appropriate for participation of the patient in the trial.

history of allergic reactions to blood products sofa scale >12 points absolute contraindication for administration of plasma participation in other blinded clinical trial projected life expectancy less than 3 months any condition perceived by the investigator as not appropriate for participation of the patient in the trial.

1. history of allergic reactions to blood products 2. sofa scale >12 points 3. absolute contraindication for administration of plasma 4. participation in other blinded clinical trial 5. projected life expectancy less than 3 months 6. any condition perceived by the investigator as not appropriate for participation of the patient in the trial.

1. history of allergic reactions to blood products 2. sofa scale >12 points 3. absolute contraindication for administration of plasma 4. participation in other blinded clinical trial 5. projected life expectancy less than 3 months 6. any condition perceived by the investigator as not appropriate for participation of the patient in the trial.