1. cases of severe vomiting that make it difficult to take the drug orally 2. allergic to favipiravir or tocilizumab 3. pregnant and lactating women 4. subjects received specific antiviral drugs such as lopinavir / ritonavir, ribavirin, arbidol, chloroquine phosphate, hydroxychloroquine, and monoclonal antibodies within one week before admission. 5. cases of respiratory failure and requiring mechanical ventilation 6. cases of shock 7. combined organ failure requires icu monitoring and treatment 8. predicted clinically that there is no hope of survival, or cases of deep coma that do not respond to supportive treatment measures within three hours of admission 9. alanine aminotransferase / aspartate aminotransferase\> 5 times of upper limit of normal 10. neutrophils \<0.5 × 10\^9 / l, platelets less than 50 × 10\^9 / l 11. clear diagnosis of rheumatoid immunity, malignant tumors and other related diseases 12. long-term oral anti-rejection drugs or immunomodulatory drugs 13. allergic reactions to tocilizumab or any excipients 14. patients with active hepatitis, tuberculosis, and definite bacterial and fungal infections 15. organ transplant patients 16. patients with mental disorders

1. cases of severe vomiting that make it difficult to take the drug orally 2. allergic to favipiravir or tocilizumab 3. pregnant and lactating women 4. subjects received specific antiviral drugs such as lopinavir / ritonavir, ribavirin, arbidol, chloroquine phosphate, hydroxychloroquine, and monoclonal antibodies within one week before admission. 5. cases of respiratory failure and requiring mechanical ventilation 6. cases of shock 7. combined organ failure requires icu monitoring and treatment 8. predicted clinically that there is no hope of survival, or cases of deep coma that do not respond to supportive treatment measures within three hours of admission 9. alanine aminotransferase / aspartate aminotransferase\> 5 times of upper limit of normal 10. neutrophils \<0.5 × 10\^9 / l, platelets less than 50 × 10\^9 / l 11. clear diagnosis of rheumatoid immunity, malignant tumors and other related diseases 12. long-term oral anti-rejection drugs or immunomodulatory drugs 13. allergic reactions to tocilizumab or any excipients 14. patients with active hepatitis, tuberculosis, and definite bacterial and fungal infections 15. organ transplant patients 16. patients with mental disorders

cases of severe vomiting that make it difficult to take the drug orally allergic to favipiravir or tocilizumab pregnant and lactating women subjects received specific antiviral drugs such as lopinavir / ritonavir, ribavirin, arbidol, chloroquine phosphate, hydroxychloroquine, and monoclonal antibodies within one week before admission. cases of respiratory failure and requiring mechanical ventilation cases of shock combined organ failure requires icu monitoring and treatment predicted clinically that there is no hope of survival, or cases of deep coma that do not respond to supportive treatment measures within three hours of admission alanine aminotransferase / aspartate aminotransferase> 5 times of upper limit of normal neutrophils <0.5 × 10^9 / l, platelets less than 50 × 10^9 / l clear diagnosis of rheumatoid immunity, malignant tumors and other related diseases long-term oral anti-rejection drugs or immunomodulatory drugs allergic reactions to tocilizumab or any excipients patients with active hepatitis, tuberculosis, and definite bacterial and fungal infections organ transplant patients patients with mental disorders

cases of severe vomiting that make it difficult to take the drug orally allergic to favipiravir or tocilizumab pregnant and lactating women subjects received specific antiviral drugs such as lopinavir / ritonavir, ribavirin, arbidol, chloroquine phosphate, hydroxychloroquine, and monoclonal antibodies within one week before admission. cases of respiratory failure and requiring mechanical ventilation cases of shock combined organ failure requires icu monitoring and treatment predicted clinically that there is no hope of survival, or cases of deep coma that do not respond to supportive treatment measures within three hours of admission alanine aminotransferase / aspartate aminotransferase> 5 times of upper limit of normal neutrophils <0.5 × 10^9 / l, platelets less than 50 × 10^9 / l clear diagnosis of rheumatoid immunity, malignant tumors and other related diseases long-term oral anti-rejection drugs or immunomodulatory drugs allergic reactions to tocilizumab or any excipients patients with active hepatitis, tuberculosis, and definite bacterial and fungal infections organ transplant patients patients with mental disorders

1. cases of severe vomiting that make it difficult to take the drug orally 2. allergic to favipiravir or tocilizumab 3. pregnant and lactating women 4. subjects received specific antiviral drugs such as lopinavir / ritonavir, ribavirin, arbidol, chloroquine phosphate, hydroxychloroquine, and monoclonal antibodies within one week before admission. 5. cases of respiratory failure and requiring mechanical ventilation 6. cases of shock 7. combined organ failure requires icu monitoring and treatment 8. predicted clinically that there is no hope of survival, or cases of deep coma that do not respond to supportive treatment measures within three hours of admission 9. alanine aminotransferase / aspartate aminotransferase> 5 times of upper limit of normal 10. neutrophils <0.5 × 10^9 / l, platelets less than 50 × 10^9 / l 11. clear diagnosis of rheumatoid immunity, malignant tumors and other related diseases 12. long-term oral anti-rejection drugs or immunomodulatory drugs 13. allergic reactions to tocilizumab or any excipients 14. patients with active hepatitis, tuberculosis, and definite bacterial and fungal infections 15. organ transplant patients 16. patients with mental disorders

1. cases of severe vomiting that make it difficult to take the drug orally 2. allergic to favipiravir or tocilizumab 3. pregnant and lactating women 4. subjects received specific antiviral drugs such as lopinavir / ritonavir, ribavirin, arbidol, chloroquine phosphate, hydroxychloroquine, and monoclonal antibodies within one week before admission. 5. cases of respiratory failure and requiring mechanical ventilation 6. cases of shock 7. combined organ failure requires icu monitoring and treatment 8. predicted clinically that there is no hope of survival, or cases of deep coma that do not respond to supportive treatment measures within three hours of admission 9. alanine aminotransferase / aspartate aminotransferase> 5 times of upper limit of normal 10. neutrophils <0.5 × 10^9 / l, platelets less than 50 × 10^9 / l 11. clear diagnosis of rheumatoid immunity, malignant tumors and other related diseases 12. long-term oral anti-rejection drugs or immunomodulatory drugs 13. allergic reactions to tocilizumab or any excipients 14. patients with active hepatitis, tuberculosis, and definite bacterial and fungal infections 15. organ transplant patients 16. patients with mental disorders