Subjects entering the ICU and presenting with confirmed or suspected COVID-19-related ARDS will be enrolled in the trial. 1. Aged 18 to 80 years (inclusive at the time of consent) 2. Subjects are diagnosed with moderate to severe ARDS that has been present for less than 3 days 3. Meet Berlin Definition 1) Must have a partial pressure of arterial O2 (PaO2)/ fraction of inspired O2 (FiO2) less than or equal to 200 mmHg on invasive or non-invasive ventilation with the level of positive end-expiratory pressure (PEEP) or continuous positive pressure (CPAP) greater than or equal to 5cmH2O. 2) Bilateral opacities not fully explained by effusion, lobar or lung collapse, or nodules by chest X-ray or CT 3) Respiratory failure not fully explained by heart failure or fluid overload In the opinion of the treating clinicians, likely to survive beyond the day after tomorrow. 4. Subjects who are consented

Subjects entering the ICU and presenting with confirmed or suspected COVID-19-related ARDS will be enrolled in the trial. 1. Aged 18 to 80 years (inclusive at the time of consent) 2. Subjects are diagnosed with moderate to severe ARDS that has been present for less than 3 days 3. Meet Berlin Definition 1) Must have a partial pressure of arterial O2 (PaO2)/ fraction of inspired O2 (FiO2) less than or equal to 200 mmHg on invasive or non-invasive ventilation with the level of positive end-expiratory pressure (PEEP) or continuous positive pressure (CPAP) greater than or equal to 5cmH2O. 2) Bilateral opacities not fully explained by effusion, lobar or lung collapse, or nodules by chest X-ray or CT 3) Respiratory failure not fully explained by heart failure or fluid overload In the opinion of the treating clinicians, likely to survive beyond the day after tomorrow. 4. Subjects who are consented