1. Subjects who have <55 ml/min/BSA 2. Subjects who require ECMO 3. Subjects who require a therapeutic dose of heparin or who are receiving oral anticoagulants, or received warfarin, factor Xa inhibitors within last 24 hours 4. Subjects who have Absolute Neutrophil Count (ANC) <1000/mL, 6. Subjects who have activated Partial Thromboplastin Time (aPTT) >55 s, 7. Severe anaemia (haemoglobin, 8. Bleeding in the past 24 hours requiring blood transfusion, 9. Subjects who have the following chronic organ dysfunction or immunosuppression

1. Subjects who have <55 ml/min/BSA 2. Subjects who require ECMO 3. Subjects who require a therapeutic dose of heparin or who are receiving oral anticoagulants, or received warfarin, factor Xa inhibitors within last 24 hours 4. Subjects who have Absolute Neutrophil Count (ANC) <1000/mL, 6. Subjects who have activated Partial Thromboplastin Time (aPTT) >55 s, 7. Severe anaemia (haemoglobin, 8. Bleeding in the past 24 hours requiring blood transfusion, 9. Subjects who have the following chronic organ dysfunction or immunosuppression