1. Adult, aged greater than or equal to 18 years. 2. PCR or RAT-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. 3. Intention for community-based management. 4. Eligibility to at least one recruiting domain. 5. Participant & treating clinician are willing and able to comply with all study requirements, including treatment, timing and/or nature of required assessments, and. 6. Documented informed consent

1. Adult, aged greater than or equal to 18 years. 2. PCR or RAT-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. 3. Intention for community-based management. 4. Eligibility to at least one recruiting domain. 5. Participant & treating clinician are willing and able to comply with all study requirements, including treatment, timing and/or nature of required assessments, and. 6. Documented informed consent

1. Adult, aged greater than or equal to 18 years. 2. PCR-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. 3. Intention for community-based management. 4. Eligibility to at least one recruiting domain. 5. Participant & treating clinician are willing and able to comply with all study requirements, including treatment, timing and/or nature of required assessments, and. 6. Documented informed consent

1. Adult, aged greater than or equal to 18 years. 2. PCR-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. 3. Intention for community-based management. 4. Eligibility to at least one recruiting domain. 5. Participant & treating clinician are willing and able to comply with all study requirements, including treatment, timing and/or nature of required assessments, and. 6. Documented informed consent

1) Adults with PCR-confirmed COVID-19 (regardless of symptom status) 2) In one of two strata: a) Participants aged 50 to 64 years with any of the following listed comorbidities: - Coronary (ischaemic) heart disease - Hypertension - Asthma - Chronic obstructive pulmonary disease (COPD) - Diabetes - Previous stroke - Active cancer - On immunosuppressive therapy: long-term oral steroids (equivalent to prednisone 20mg daily or greater) or other long-term immunosuppression. OR b) Participants aged 65 years and older (regardless of comorbidity) 3) Willing and able to comply with all study requirements, including treatment, timing and/or nature of required assessments. 4) Documented informed consent, either written or e-consent.

1) Adults with PCR-confirmed COVID-19 (regardless of symptom status) 2) In one of two strata: a) Participants aged 50 to 64 years with any of the following listed comorbidities: - Coronary (ischaemic) heart disease - Hypertension - Asthma - Chronic obstructive pulmonary disease (COPD) - Diabetes - Previous stroke - Active cancer - On immunosuppressive therapy: long-term oral steroids (equivalent to prednisone 20mg daily or greater) or other long-term immunosuppression. OR b) Participants aged 65 years and older (regardless of comorbidity) 3) Willing and able to comply with all study requirements, including treatment, timing and/or nature of required assessments. 4) Documented informed consent, either written or e-consent.