1. Currently pregnant or breast-feeding 2. Any medical condition which, in the opinion of the Investigator, may affect the participant’s safety or study participation and conduct

1. Currently pregnant or breast-feeding 2. Any medical condition which, in the opinion of the Investigator, may affect the participant’s safety or study participation and conduct

1. Hypoxaemia (SpO2 < 94% on room air) 2. Resting Heart Rate > 110 beats per minute 3. Systolic Blood Pressure < 90 millimetres of mercury 4. Currently pregnant or breast-feeding

1. Hypoxaemia (SpO2 < 94% on room air) 2. Resting Heart Rate > 110 beats per minute 3. Systolic Blood Pressure < 90 millimetres of mercury 4. Currently pregnant or breast-feeding

1) Hypoxaemia (SpO2 < 94% on room air) 2) Resting HR > 110 bpm 3) Systolic BP < 90 mmHg 4) Pregnancy or lactation. 5) Presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule, including alcohol dependence or drug abuse 6) If there are definite indications or contraindications to any of the study medications in the view of the doctor responsible for the care of the patient

1) Hypoxaemia (SpO2 < 94% on room air) 2) Resting HR > 110 bpm 3) Systolic BP < 90 mmHg 4) Pregnancy or lactation. 5) Presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule, including alcohol dependence or drug abuse 6) If there are definite indications or contraindications to any of the study medications in the view of the doctor responsible for the care of the patient