• Age less than 18yo or pregnant or lactating female • Allergy to Zn • Severe hepatic impairment defined as Child C liver disease. • eGFR equal to or less than 30 mL/min/1.73 m2 (defined using CKD-EPI SCr formula) • History of any organ transplant which requires active immunosuppressive treatment which can interfere with kidney function • If a patient required cardiopulmonary resuscitation (CPR) within 14 days • DNR (do not resuscitate) DNI (do not intubate) orders • Death is deemed imminent or inevitable during this admission, and either the attending physician, patient or substitute decision-maker is not committed to active treatment • Already receiving dialysis (either acute or chronic) or imminent need of dialysis at the time of enrolment • Patients with known HIV infection • Patients with a known or suspected history of oxalate nephropathy or hyperoxaluria, scurvy, chronic iron overload, G-6PD deficiency • Clinician expects to prescribe Zinc for another indication • Patients with known haemochromatosis.

• Age less than 18yo or pregnant or lactating female • Allergy to Zn • Severe hepatic impairment defined as Child C liver disease. • eGFR equal to or less than 30 mL/min/1.73 m2 (defined using CKD-EPI SCr formula) • History of any organ transplant which requires active immunosuppressive treatment which can interfere with kidney function • If a patient required cardiopulmonary resuscitation (CPR) within 14 days • DNR (do not resuscitate) DNI (do not intubate) orders • Death is deemed imminent or inevitable during this admission, and either the attending physician, patient or substitute decision-maker is not committed to active treatment • Already receiving dialysis (either acute or chronic) or imminent need of dialysis at the time of enrolment • Patients with known HIV infection • Patients with a known or suspected history of oxalate nephropathy or hyperoxaluria, scurvy, chronic iron overload, G-6PD deficiency • Clinician expects to prescribe Zinc for another indication • Patients with known haemochromatosis.