inclusion criteria: 1. participants of 18 years of age or older, at the time of signing of informed consent 2. participants who have a positive sars-cov-2 test result 3. participants who have one or more covid-19 symptoms, such as fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, shortness of breath with exertion 4. participants who have spo2≤93% on room air at sea level or pao2/fio2≤ 300 5. participants who must agree to adhere to contraception restrictions 6. participants who understand and agree to comply with planned study procedures 7. participants or legally authorized representatives can give written informed consent approved by the ethical review board governing the site 8. capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in this protocol

inclusion criteria: 1. participants of 18 years of age or older, at the time of signing of informed consent 2. participants who have a positive sars-cov-2 test result 3. participants who have one or more covid-19 symptoms, such as fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, shortness of breath with exertion 4. participants who have spo2≤93% on room air at sea level or pao2/fio2≤ 300 5. participants who must agree to adhere to contraception restrictions 6. participants who understand and agree to comply with planned study procedures 7. participants or legally authorized representatives can give written informed consent approved by the ethical review board governing the site 8. capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in this protocol

inclusion criteria: participants of 18 years of age or older, at the time of signing of informed consent participants who have a positive sars-cov-2 test result participants who have one or more covid-19 symptoms, such as fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, shortness of breath with exertion participants who have spo2≤93% on room air at sea level or pao2/fio2≤ 300 participants who must agree to adhere to contraception restrictions participants who understand and agree to comply with planned study procedures participants or legally authorized representatives can give written informed consent approved by the ethical review board governing the site capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in this protocol

inclusion criteria: participants of 18 years of age or older, at the time of signing of informed consent participants who have a positive sars-cov-2 test result participants who have one or more covid-19 symptoms, such as fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, shortness of breath with exertion participants who have spo2≤93% on room air at sea level or pao2/fio2≤ 300 participants who must agree to adhere to contraception restrictions participants who understand and agree to comply with planned study procedures participants or legally authorized representatives can give written informed consent approved by the ethical review board governing the site capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in this protocol