inclusion criteria: 1. 18 to 60 years of age. 2. verified healthy condition according to the data of standard clinical, laboratory and instrumental examination methods. 3. for women being in an active reproductive period: consent to adhere to appropriate methods of contraception during the entire period of the participation in the study and for 1 month after the completion of the participation in the study (appropriate methods of contraception include abstinence from sexual intercourse or any two of the following methods: an intrauterine device (intrauterine device without release and with a release of a local hormonal drug), diaphragm, spermicides, cervical caps, oral contraceptives, contraceptive sponge and/or condom); for men: consent to adhere to appropriate dual barrier methods of contraception during the entire period of the participation in the study and 1 month after completion of the participation in the study. 4. body mass index (bmi): 18.5≤ bmi≤30 kg/m2. 5. negative breath alcohol test. 6. negative laboratory blood tests for hiv, syphilis and hepatitis b and c. 7. ability and willingness to attend all scheduled visits and undergo all procedures and examinations planned by the protocol. 8. signed and dated informed consent to participate in the study.

inclusion criteria: 1. 18 to 60 years of age. 2. verified healthy condition according to the data of standard clinical, laboratory and instrumental examination methods. 3. for women being in an active reproductive period: consent to adhere to appropriate methods of contraception during the entire period of the participation in the study and for 1 month after the completion of the participation in the study (appropriate methods of contraception include abstinence from sexual intercourse or any two of the following methods: an intrauterine device (intrauterine device without release and with a release of a local hormonal drug), diaphragm, spermicides, cervical caps, oral contraceptives, contraceptive sponge and/or condom); for men: consent to adhere to appropriate dual barrier methods of contraception during the entire period of the participation in the study and 1 month after completion of the participation in the study. 4. body mass index (bmi): 18.5≤ bmi≤30 kg/m2. 5. negative breath alcohol test. 6. negative laboratory blood tests for hiv, syphilis and hepatitis b and c. 7. ability and willingness to attend all scheduled visits and undergo all procedures and examinations planned by the protocol. 8. signed and dated informed consent to participate in the study.

inclusion criteria: 18 to 60 years of age. verified healthy condition according to the data of standard clinical, laboratory and instrumental examination methods. for women being in an active reproductive period: consent to adhere to appropriate methods of contraception during the entire period of the participation in the study and for 1 month after the completion of the participation in the study (appropriate methods of contraception include abstinence from sexual intercourse or any two of the following methods: an intrauterine device (intrauterine device without release and with a release of a local hormonal drug), diaphragm, spermicides, cervical caps, oral contraceptives, contraceptive sponge and/or condom); for men: consent to adhere to appropriate dual barrier methods of contraception during the entire period of the participation in the study and 1 month after completion of the participation in the study. body mass index (bmi): 18.5≤ bmi≤30 kg/m2. negative breath alcohol test. negative laboratory blood tests for hiv, syphilis and hepatitis b and c. ability and willingness to attend all scheduled visits and undergo all procedures and examinations planned by the protocol. signed and dated informed consent to participate in the study.

inclusion criteria: 18 to 60 years of age. verified healthy condition according to the data of standard clinical, laboratory and instrumental examination methods. for women being in an active reproductive period: consent to adhere to appropriate methods of contraception during the entire period of the participation in the study and for 1 month after the completion of the participation in the study (appropriate methods of contraception include abstinence from sexual intercourse or any two of the following methods: an intrauterine device (intrauterine device without release and with a release of a local hormonal drug), diaphragm, spermicides, cervical caps, oral contraceptives, contraceptive sponge and/or condom); for men: consent to adhere to appropriate dual barrier methods of contraception during the entire period of the participation in the study and 1 month after completion of the participation in the study. body mass index (bmi): 18.5≤ bmi≤30 kg/m2. negative breath alcohol test. negative laboratory blood tests for hiv, syphilis and hepatitis b and c. ability and willingness to attend all scheduled visits and undergo all procedures and examinations planned by the protocol. signed and dated informed consent to participate in the study.