* concomitant use of another anticoagulant * known pregnancy * known hypersensitivity to sulodexide * need for hospital care at screening * renal insufficiency with crcl \<30ml/min or continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. * blood platelet count \< 30 000/µl * other conditions that are judged to carry an increased risk of bleeding as judged by the investigator * more than 30 days of clinical onset

* concomitant use of another anticoagulant * known pregnancy * known hypersensitivity to sulodexide * need for hospital care at screening * renal insufficiency with crcl \<30ml/min or continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. * blood platelet count \< 30 000/µl * other conditions that are judged to carry an increased risk of bleeding as judged by the investigator * more than 30 days of clinical onset

concomitant use of another anticoagulant known pregnancy known hypersensitivity to sulodexide need for hospital care at screening renal insufficiency with crcl <30ml/min or continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. blood platelet count < 30 000/µl other conditions that are judged to carry an increased risk of bleeding as judged by the investigator more than 30 days of clinical onset

concomitant use of another anticoagulant known pregnancy known hypersensitivity to sulodexide need for hospital care at screening renal insufficiency with crcl <30ml/min or continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. blood platelet count < 30 000/µl other conditions that are judged to carry an increased risk of bleeding as judged by the investigator more than 30 days of clinical onset