inclusion criteria: a subject will be eligible for inclusion in the study if he/she fulfils the following criteria: 1. adult males or females aged 18 years or older 2. rt-pcr confirmation for sars-cov2 infection from respiratory tract specimens) 3. currently hospitalized and intubated covid-19 patients 4. p/f ratio of \<100 mmhg with peep ≥ 5 cm h20 5. systolic blood pressure below 90 mmhg 6. written informed consent

inclusion criteria: a subject will be eligible for inclusion in the study if he/she fulfils the following criteria: 1. adult males or females aged 18 years or older 2. rt-pcr confirmation for sars-cov2 infection from respiratory tract specimens) 3. currently hospitalized and intubated covid-19 patients 4. p/f ratio of \<100 mmhg with peep ≥ 5 cm h20 5. systolic blood pressure below 90 mmhg 6. written informed consent

inclusion criteria: a subject will be eligible for inclusion in the study if he/she fulfils the following criteria: adult males or females aged 18 years or older rt-pcr confirmation for sars-cov2 infection from respiratory tract specimens) currently hospitalized and intubated covid-19 patients p/f ratio of <100 mmhg with peep ≥ 5 cm h20 systolic blood pressure below 90 mmhg written informed consent

inclusion criteria: a subject will be eligible for inclusion in the study if he/she fulfils the following criteria: adult males or females aged 18 years or older rt-pcr confirmation for sars-cov2 infection from respiratory tract specimens) currently hospitalized and intubated covid-19 patients p/f ratio of <100 mmhg with peep ≥ 5 cm h20 systolic blood pressure below 90 mmhg written informed consent