Changes in physical examinations;Changes in vital signs;Clinically relevant changes in laboratory measurement;Frequency of solicited local reactogenicity adverse events (AE);Frequency of solicited systemic reactogenicity adverse events (AE);Grade of solicited local reactogenicity adverse events (AE);Grade of solicited systemic reactogenicity adverse events (AE);Treatment-emergent, clinically significant changes in physical examinations;Treatment-emergent, clinically significant changes in vital signs

Changes in physical examinations;Changes in vital signs;Clinically relevant changes in laboratory measurement;Frequency of solicited local reactogenicity adverse events (AE);Frequency of solicited systemic reactogenicity adverse events (AE);Grade of solicited local reactogenicity adverse events (AE);Grade of solicited systemic reactogenicity adverse events (AE);Treatment-emergent, clinically significant changes in physical examinations;Treatment-emergent, clinically significant changes in vital signs