subjects meeting any of the following criteria will be excluded from the study: 1. is acutely ill or febrile within 48 hours before or use of antipyretic or analgesic medication within 24 hours before planned administration of study vaccine. (fever is defined as a body temperature is 38.0 °c. subjects with mild illness and fever may be enrolled in the study at the discretion of the investigator), 2. those who have used more than a single dose of nonsteroidal anti-inflammatory drugs (nsaids) in the last 24 hours for a reason other than fever, 3. subjects who are pregnancy or breastfeeding plan within (at least) 1 year following the second dose of vaccine, 4. those with a history of sars-cov-2 (within the last 12 months), 5. individuals with a current positive (pcr-based viral rna detection) or past positive (serological testing or pcr-based viral rna detection) diagnostic test result for sars-cov-2 infection, 6. prior administration of an investigational or approved coronavirus (sars-cov, sars-cov-2, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19, 7. subjects with a history of cardiac diseases (cardiovascular disease, serious arrythmia, coronary artery disease, heart failure, cardiomyopathies, pulmonary hypertension etc.), 8. subjects with uncontrolled hypertension, 9. subjects with a first-degree relative with a history of coronary artery disease at an early age (presence of coronary artery disease before 55 years of age in males and 65 years of age in females), 10. subjects with morbid obesity (body mass index (bmi) ≥ 40), 11. subjects with a history of autoimmune disease or an active autoimmune disease requiring therapeutic intervention, including but not limited to: systemic or cutaneous lupus erythematosus, autoimmune arthritis/rheumatoid arthritis, guillain-barré syndrome, multiple sclerosis, sjögren's syndrome, idiopathic thrombocytopenia purpura, glomerulonephritis, autoimmune thyroiditis, giant cell arteritis (temporal arteritis), psoriasis, and autoimmune bullous diseases, 12. subjects with history of severe allergic reaction (i.e., anaphylaxis, generalized urticaria, angioedema, or other significant reaction) to any licensed or investigational vaccine or to any of the constituents of coronavac or turkovac, 13. subjects who have bleeding disorder considered a contraindication to intramuscular injection or phlebotomy, 14. subjects who have immunosuppressive or immunodeficiency state (including hiv), asplenia, recurrent severe infections, 15. subjects who received or planned to receive a licensed, live replicating vaccine (any vaccine other than the covid-19 vaccine) within 28 days before or after the first study vaccination or a licensed inactivated or nonreplicating vaccine (any vaccine other than the covid-19 vaccine) within 14 days before or after first study vaccination, 16. subjects who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, e.g., for cancer or an autoimmune disease, within 6 months prior to screening, or planned receipt throughout the study. if systemic corticosteroids have been administered short term (\<14 days) for treatment of an acute illness, participants should not be enrolled into the study until corticosteroid therapy has been discontinued for at least 28 days before study vaccine administration. inhaled/nebulized, intra-articular, intrabursal, or topical (skin or eyes) corticosteroids are permitted, 17. to be using an immunostimulant, immune-modifying supplementary drug or herbal product or to have used it in the last month, 18. subjects who have received systemic immunoglobulin or blood products in the past 12 months, or who plan to receive such products during the study, 19. investigator, site coordinators, employees of tuseb or the clinical research organization (cro) directly involved in the conduct of the study, or site staff members otherwise supervised by the investigator or immediate family members of any of the previously mentioned individuals. 20. subjects who have previously received any covid-19 vaccines. exclusion criteria for the second dose of vaccine: 1. before the second vaccination, in the case of an unresolved acute illness or in the acute phase of a chronic illness, the investigator should exclude covid-19 and assess if the acute disease can recover in a short term. 2. if there is an adverse event after the first dose or newly occurred non-compliance with the inclusion/exclusion criteria which will be assessed by the investigator whether the study subjects can continue or not.

subjects meeting any of the following criteria will be excluded from the study: 1. is acutely ill or febrile within 48 hours before or use of antipyretic or analgesic medication within 24 hours before planned administration of study vaccine. (fever is defined as a body temperature is 38.0 °c. subjects with mild illness and fever may be enrolled in the study at the discretion of the investigator), 2. those who have used more than a single dose of nonsteroidal anti-inflammatory drugs (nsaids) in the last 24 hours for a reason other than fever, 3. subjects who are pregnancy or breastfeeding plan within (at least) 1 year following the second dose of vaccine, 4. those with a history of sars-cov-2 (within the last 12 months), 5. individuals with a current positive (pcr-based viral rna detection) or past positive (serological testing or pcr-based viral rna detection) diagnostic test result for sars-cov-2 infection, 6. prior administration of an investigational or approved coronavirus (sars-cov, sars-cov-2, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19, 7. subjects with a history of cardiac diseases (cardiovascular disease, serious arrythmia, coronary artery disease, heart failure, cardiomyopathies, pulmonary hypertension etc.), 8. subjects with uncontrolled hypertension, 9. subjects with a first-degree relative with a history of coronary artery disease at an early age (presence of coronary artery disease before 55 years of age in males and 65 years of age in females), 10. subjects with morbid obesity (body mass index (bmi) ≥ 40), 11. subjects with a history of autoimmune disease or an active autoimmune disease requiring therapeutic intervention, including but not limited to: systemic or cutaneous lupus erythematosus, autoimmune arthritis/rheumatoid arthritis, guillain-barré syndrome, multiple sclerosis, sjögren's syndrome, idiopathic thrombocytopenia purpura, glomerulonephritis, autoimmune thyroiditis, giant cell arteritis (temporal arteritis), psoriasis, and autoimmune bullous diseases, 12. subjects with history of severe allergic reaction (i.e., anaphylaxis, generalized urticaria, angioedema, or other significant reaction) to any licensed or investigational vaccine or to any of the constituents of coronavac or turkovac, 13. subjects who have bleeding disorder considered a contraindication to intramuscular injection or phlebotomy, 14. subjects who have immunosuppressive or immunodeficiency state (including hiv), asplenia, recurrent severe infections, 15. subjects who received or planned to receive a licensed, live replicating vaccine (any vaccine other than the covid-19 vaccine) within 28 days before or after the first study vaccination or a licensed inactivated or nonreplicating vaccine (any vaccine other than the covid-19 vaccine) within 14 days before or after first study vaccination, 16. subjects who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, e.g., for cancer or an autoimmune disease, within 6 months prior to screening, or planned receipt throughout the study. if systemic corticosteroids have been administered short term (\<14 days) for treatment of an acute illness, participants should not be enrolled into the study until corticosteroid therapy has been discontinued for at least 28 days before study vaccine administration. inhaled/nebulized, intra-articular, intrabursal, or topical (skin or eyes) corticosteroids are permitted, 17. to be using an immunostimulant, immune-modifying supplementary drug or herbal product or to have used it in the last month, 18. subjects who have received systemic immunoglobulin or blood products in the past 12 months, or who plan to receive such products during the study, 19. investigator, site coordinators, employees of tuseb or the clinical research organization (cro) directly involved in the conduct of the study, or site staff members otherwise supervised by the investigator or immediate family members of any of the previously mentioned individuals. 20. subjects who have previously received any covid-19 vaccines. exclusion criteria for the second dose of vaccine: 1. before the second vaccination, in the case of an unresolved acute illness or in the acute phase of a chronic illness, the investigator should exclude covid-19 and assess if the acute disease can recover in a short term. 2. if there is an adverse event after the first dose or newly occurred non-compliance with the inclusion/exclusion criteria which will be assessed by the investigator whether the study subjects can continue or not.

subjects meeting any of the following criteria will be excluded from the study: is acutely ill or febrile within 48 hours before or use of antipyretic or analgesic medication within 24 hours before planned administration of study vaccine. (fever is defined as a body temperature is 38.0 °c. subjects with mild illness and fever may be enrolled in the study at the discretion of the investigator), those who have used more than a single dose of nonsteroidal anti-inflammatory drugs (nsaids) in the last 24 hours for a reason other than fever, subjects who are pregnancy or breastfeeding plan within (at least) 1 year following the second dose of vaccine, those with a history of sars-cov-2 (within the last 12 months), individuals with a current positive (pcr-based viral rna detection) or past positive (serological testing or pcr-based viral rna detection) diagnostic test result for sars-cov-2 infection, prior administration of an investigational or approved coronavirus (sars-cov, sars-cov-2, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19, subjects with a history of cardiac diseases (cardiovascular disease, serious arrythmia, coronary artery disease, heart failure, cardiomyopathies, pulmonary hypertension etc.), subjects with uncontrolled hypertension, subjects with a first-degree relative with a history of coronary artery disease at an early age (presence of coronary artery disease before 55 years of age in males and 65 years of age in females), subjects with morbid obesity (body mass index (bmi) ≥ 40), subjects with a history of autoimmune disease or an active autoimmune disease requiring therapeutic intervention, including but not limited to: systemic or cutaneous lupus erythematosus, autoimmune arthritis/rheumatoid arthritis, guillain-barré syndrome, multiple sclerosis, sjögren's syndrome, idiopathic thrombocytopenia purpura, glomerulonephritis, autoimmune thyroiditis, giant cell arteritis (temporal arteritis), psoriasis, and autoimmune bullous diseases, subjects with history of severe allergic reaction (i.e., anaphylaxis, generalized urticaria, angioedema, or other significant reaction) to any licensed or investigational vaccine or to any of the constituents of coronavac or turkovac, subjects who have bleeding disorder considered a contraindication to intramuscular injection or phlebotomy, subjects who have immunosuppressive or immunodeficiency state (including hiv), asplenia, recurrent severe infections, subjects who received or planned to receive a licensed, live replicating vaccine (any vaccine other than the covid-19 vaccine) within 28 days before or after the first study vaccination or a licensed inactivated or nonreplicating vaccine (any vaccine other than the covid-19 vaccine) within 14 days before or after first study vaccination, subjects who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, e.g., for cancer or an autoimmune disease, within 6 months prior to screening, or planned receipt throughout the study. if systemic corticosteroids have been administered short term (<14 days) for treatment of an acute illness, participants should not be enrolled into the study until corticosteroid therapy has been discontinued for at least 28 days before study vaccine administration. inhaled/nebulized, intra-articular, intrabursal, or topical (skin or eyes) corticosteroids are permitted, to be using an immunostimulant, immune-modifying supplementary drug or herbal product or to have used it in the last month, subjects who have received systemic immunoglobulin or blood products in the past 12 months, or who plan to receive such products during the study, investigator, site coordinators, employees of tuseb or the clinical research organization (cro) directly involved in the conduct of the study, or site staff members otherwise supervised by the investigator or immediate family members of any of the previously mentioned individuals. subjects who have previously received any covid-19 vaccines. exclusion criteria for the second dose of vaccine: before the second vaccination, in the case of an unresolved acute illness or in the acute phase of a chronic illness, the investigator should exclude covid-19 and assess if the acute disease can recover in a short term. if there is an adverse event after the first dose or newly occurred non-compliance with the inclusion/exclusion criteria which will be assessed by the investigator whether the study subjects can continue or not.

subjects meeting any of the following criteria will be excluded from the study: is acutely ill or febrile within 48 hours before or use of antipyretic or analgesic medication within 24 hours before planned administration of study vaccine. (fever is defined as a body temperature is 38.0 °c. subjects with mild illness and fever may be enrolled in the study at the discretion of the investigator), those who have used more than a single dose of nonsteroidal anti-inflammatory drugs (nsaids) in the last 24 hours for a reason other than fever, subjects who are pregnancy or breastfeeding plan within (at least) 1 year following the second dose of vaccine, those with a history of sars-cov-2 (within the last 12 months), individuals with a current positive (pcr-based viral rna detection) or past positive (serological testing or pcr-based viral rna detection) diagnostic test result for sars-cov-2 infection, prior administration of an investigational or approved coronavirus (sars-cov, sars-cov-2, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19, subjects with a history of cardiac diseases (cardiovascular disease, serious arrythmia, coronary artery disease, heart failure, cardiomyopathies, pulmonary hypertension etc.), subjects with uncontrolled hypertension, subjects with a first-degree relative with a history of coronary artery disease at an early age (presence of coronary artery disease before 55 years of age in males and 65 years of age in females), subjects with morbid obesity (body mass index (bmi) ≥ 40), subjects with a history of autoimmune disease or an active autoimmune disease requiring therapeutic intervention, including but not limited to: systemic or cutaneous lupus erythematosus, autoimmune arthritis/rheumatoid arthritis, guillain-barré syndrome, multiple sclerosis, sjögren's syndrome, idiopathic thrombocytopenia purpura, glomerulonephritis, autoimmune thyroiditis, giant cell arteritis (temporal arteritis), psoriasis, and autoimmune bullous diseases, subjects with history of severe allergic reaction (i.e., anaphylaxis, generalized urticaria, angioedema, or other significant reaction) to any licensed or investigational vaccine or to any of the constituents of coronavac or turkovac, subjects who have bleeding disorder considered a contraindication to intramuscular injection or phlebotomy, subjects who have immunosuppressive or immunodeficiency state (including hiv), asplenia, recurrent severe infections, subjects who received or planned to receive a licensed, live replicating vaccine (any vaccine other than the covid-19 vaccine) within 28 days before or after the first study vaccination or a licensed inactivated or nonreplicating vaccine (any vaccine other than the covid-19 vaccine) within 14 days before or after first study vaccination, subjects who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, e.g., for cancer or an autoimmune disease, within 6 months prior to screening, or planned receipt throughout the study. if systemic corticosteroids have been administered short term (<14 days) for treatment of an acute illness, participants should not be enrolled into the study until corticosteroid therapy has been discontinued for at least 28 days before study vaccine administration. inhaled/nebulized, intra-articular, intrabursal, or topical (skin or eyes) corticosteroids are permitted, to be using an immunostimulant, immune-modifying supplementary drug or herbal product or to have used it in the last month, subjects who have received systemic immunoglobulin or blood products in the past 12 months, or who plan to receive such products during the study, investigator, site coordinators, employees of tuseb or the clinical research organization (cro) directly involved in the conduct of the study, or site staff members otherwise supervised by the investigator or immediate family members of any of the previously mentioned individuals. subjects who have previously received any covid-19 vaccines. exclusion criteria for the second dose of vaccine: before the second vaccination, in the case of an unresolved acute illness or in the acute phase of a chronic illness, the investigator should exclude covid-19 and assess if the acute disease can recover in a short term. if there is an adverse event after the first dose or newly occurred non-compliance with the inclusion/exclusion criteria which will be assessed by the investigator whether the study subjects can continue or not.

subjects meeting any of the following criteria will be excluded from the study: is acutely ill or febrile within 48 hours before or use of antipyretic or analgesic medication within 24 hours before planned administration of study vaccine. (fever is defined as a body temperature is 38.0 °c. subjects with mild illness and fever may be enrolled in the study at the discretion of the investigator), subjects who are pregnancy or breastfeeding plan within (at least) 1 year following the second dose of vaccine, individuals with a current positive (pcr-based viral rna detection) or past positive (serological testing or pcr-based viral rna detection) diagnostic test result for sars-cov-2 infection, prior administration of an investigational or approved coronavirus (sars-cov, sars-cov-2, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19, subjects with a history of cardiac diseases (cardiovascular disease, serious arrythmia, coronary artery disease, heart failure, cardiomyopathies, pulmonary hypertension etc.), subjects with uncontrolled hypertension, subjects with a first-degree relative with a history of coronary artery disease at an early age (presence of coronary artery disease before 55 years of age in males and 65 years of age in females), subjects with morbid obesity (body mass index (bmi) ≥ 40), subjects with a history of autoimmune disease or an active autoimmune disease requiring therapeutic intervention, including but not limited to: systemic or cutaneous lupus erythematosus, autoimmune arthritis/rheumatoid arthritis, guillain-barré syndrome, multiple sclerosis, sjögren's syndrome, idiopathic thrombocytopenia purpura, glomerulonephritis, autoimmune thyroiditis, giant cell arteritis (temporal arteritis), psoriasis, and autoimmune bullous diseases, subjects with history of severe allergic reaction (i.e., anaphylaxis, generalized urticaria, angioedema, or other significant reaction) to any licensed or investigational vaccine or to any of the constituents of coronavac or turkovac, subjects who have bleeding disorder considered a contraindication to intramuscular injection or phlebotomy, subjects who have immunosuppressive or immunodeficiency state (including hiv), asplenia, recurrent severe infections, subjects who received or planned to receive a licensed, live replicating vaccine (any vaccine other than the covid-19 vaccine) within 28 days before or after the first study vaccination or a licensed inactivated or nonreplicating vaccine (any vaccine other than the covid-19 vaccine) within 14 days before or after first study vaccination, subjects who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, e.g., for cancer or an autoimmune disease, within 6 months prior to screening, or planned receipt throughout the study. if systemic corticosteroids have been administered short term (<14 days) for treatment of an acute illness, participants should not be enrolled into the study until corticosteroid therapy has been discontinued for at least 28 days before study vaccine administration. inhaled/nebulized, intra-articular, intrabursal, or topical (skin or eyes) corticosteroids are permitted, to be using an immunostimulant, immune-modifying supplementary drug or herbal product or to have used it in the last month, subjects who have received systemic immunoglobulin or blood products in the past 12 months, or who plan to receive such products during the study, investigator, site coordinators, employees of tuseb or the clinical research organization (cro) directly involved in the conduct of the study, or site staff members otherwise supervised by the investigator or immediate family members of any of the previously mentioned individuals. exclusion criteria for the second dose of vaccine: before the second vaccination, in the case of an unresolved acute illness or in the acute phase of a chronic illness, the investigator should exclude covid-19 and assess if the acute disease can recover in a short term. if there is an adverse event after the first dose or newly occurred non-compliance with the inclusion/exclusion criteria which will be assessed by the investigator whether the study subjects can continue or not.

subjects meeting any of the following criteria will be excluded from the study: is acutely ill or febrile within 48 hours before or use of antipyretic or analgesic medication within 24 hours before planned administration of study vaccine. (fever is defined as a body temperature is 38.0 °c. subjects with mild illness and fever may be enrolled in the study at the discretion of the investigator), subjects who are pregnancy or breastfeeding plan within (at least) 1 year following the second dose of vaccine, individuals with a current positive (pcr-based viral rna detection) or past positive (serological testing or pcr-based viral rna detection) diagnostic test result for sars-cov-2 infection, prior administration of an investigational or approved coronavirus (sars-cov, sars-cov-2, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19, subjects with a history of cardiac diseases (cardiovascular disease, serious arrythmia, coronary artery disease, heart failure, cardiomyopathies, pulmonary hypertension etc.), subjects with uncontrolled hypertension, subjects with a first-degree relative with a history of coronary artery disease at an early age (presence of coronary artery disease before 55 years of age in males and 65 years of age in females), subjects with morbid obesity (body mass index (bmi) ≥ 40), subjects with a history of autoimmune disease or an active autoimmune disease requiring therapeutic intervention, including but not limited to: systemic or cutaneous lupus erythematosus, autoimmune arthritis/rheumatoid arthritis, guillain-barré syndrome, multiple sclerosis, sjögren's syndrome, idiopathic thrombocytopenia purpura, glomerulonephritis, autoimmune thyroiditis, giant cell arteritis (temporal arteritis), psoriasis, and autoimmune bullous diseases, subjects with history of severe allergic reaction (i.e., anaphylaxis, generalized urticaria, angioedema, or other significant reaction) to any licensed or investigational vaccine or to any of the constituents of coronavac or turkovac, subjects who have bleeding disorder considered a contraindication to intramuscular injection or phlebotomy, subjects who have immunosuppressive or immunodeficiency state (including hiv), asplenia, recurrent severe infections, subjects who received or planned to receive a licensed, live replicating vaccine (any vaccine other than the covid-19 vaccine) within 28 days before or after the first study vaccination or a licensed inactivated or nonreplicating vaccine (any vaccine other than the covid-19 vaccine) within 14 days before or after first study vaccination, subjects who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, e.g., for cancer or an autoimmune disease, within 6 months prior to screening, or planned receipt throughout the study. if systemic corticosteroids have been administered short term (<14 days) for treatment of an acute illness, participants should not be enrolled into the study until corticosteroid therapy has been discontinued for at least 28 days before study vaccine administration. inhaled/nebulized, intra-articular, intrabursal, or topical (skin or eyes) corticosteroids are permitted, to be using an immunostimulant, immune-modifying supplementary drug or herbal product or to have used it in the last month, subjects who have received systemic immunoglobulin or blood products in the past 12 months, or who plan to receive such products during the study, investigator, site coordinators, employees of tuseb or the clinical research organization (cro) directly involved in the conduct of the study, or site staff members otherwise supervised by the investigator or immediate family members of any of the previously mentioned individuals. exclusion criteria for the second dose of vaccine: before the second vaccination, in the case of an unresolved acute illness or in the acute phase of a chronic illness, the investigator should exclude covid-19 and assess if the acute disease can recover in a short term. if there is an adverse event after the first dose or newly occurred non-compliance with the inclusion/exclusion criteria which will be assessed by the investigator whether the study subjects can continue or not.