inclusion criteria: 1. healthy adults and elderly, males and females, 18 years of age and above. healthy status will be determined by the investigator based on medical history, clinical laboratory results, vital sign measurements, and physical examination at screening. 2. subjects have been informed properly regarding the study and signed the informed consent form 3. subject will commit to comply with the instructions of the investigator and the schedule of the trial 4. female subjects of childbearing potential must agree to consistently use any methods of contraception (except the periodic abstinence) from at least 21 days prior to enrollment and through 6 months after the last vaccination. 5. participants agree not to donate bone marrow, blood, and blood products from the first study vaccine administration until 3 months after receiving the last dose of study vaccine. 6. participants must be willing to provide verifiable identification, has means to be contacted and to contact the investigator during the study.

inclusion criteria: 1. healthy adults and elderly, males and females, 18 years of age and above. healthy status will be determined by the investigator based on medical history, clinical laboratory results, vital sign measurements, and physical examination at screening. 2. subjects have been informed properly regarding the study and signed the informed consent form 3. subject will commit to comply with the instructions of the investigator and the schedule of the trial 4. female subjects of childbearing potential must agree to consistently use any methods of contraception (except the periodic abstinence) from at least 21 days prior to enrollment and through 6 months after the last vaccination. 5. participants agree not to donate bone marrow, blood, and blood products from the first study vaccine administration until 3 months after receiving the last dose of study vaccine. 6. participants must be willing to provide verifiable identification, has means to be contacted and to contact the investigator during the study.

inclusion criteria: healthy adults and elderly, males and females, 18 years of age and above. healthy status will be determined by the investigator based on medical history, clinical laboratory results, vital sign measurements, and physical examination at screening. subjects have been informed properly regarding the study and signed the informed consent form subject will commit to comply with the instructions of the investigator and the schedule of the trial female subjects of childbearing potential must agree to consistently use any methods of contraception (except the periodic abstinence) from at least 21 days prior to enrollment and through 6 months after the last vaccination. participants agree not to donate bone marrow, blood, and blood products from the first study vaccine administration until 3 months after receiving the last dose of study vaccine. participants must be willing to provide verifiable identification, has means to be contacted and to contact the investigator during the study.

inclusion criteria: healthy adults and elderly, males and females, 18 years of age and above. healthy status will be determined by the investigator based on medical history, clinical laboratory results, vital sign measurements, and physical examination at screening. subjects have been informed properly regarding the study and signed the informed consent form subject will commit to comply with the instructions of the investigator and the schedule of the trial female subjects of childbearing potential must agree to consistently use any methods of contraception (except the periodic abstinence) from at least 21 days prior to enrollment and through 6 months after the last vaccination. participants agree not to donate bone marrow, blood, and blood products from the first study vaccine administration until 3 months after receiving the last dose of study vaccine. participants must be willing to provide verifiable identification, has means to be contacted and to contact the investigator during the study.