1. subjects concomitantly enrolled or scheduled to be enrolled in another trial. 2. evolving mild, moderate, and severe illness, especially infectious diseases or fever (axillary temperature 37.5 degree celcius or more) concurrent or within 7 days prior to first study vaccination. this includes respiratory or constitutional symptoms consistent with sars-cov-2 (cough, sore throat, difficulty in breathing, etc) 3. known history of allergy to any component of the vaccines 4. history of uncontrolled coagulopathy or blood disorders contraindicating intramuscular injection 5. any autoimmune or immunodeficiency disease/condition 6. subjects who has received in the previous 4 weeks a treatment likely to alter the immune response (intravenous immunoglobulin, blood derived products, long term corticosteroid - more than 2 weeks, and so on), or anticipation of the need for immunosuppressive treatment within 6 months after last vaccination. the use of topical or nasal steroid will be permitted. inhaled glucocorticoids is prohibited. 7. chronic disease, inclusive of uncontrolled hypertension, congestive heart failure, chronic obstructive pulmonary disease, asthma, chronic urticaria, diabetes requiring use of medicine 8. any abnormality or chronic disease which according to the investigator might interfere with the assessment of the trial objectives 9. individuals who previously receive any vaccines against covid-19 10. subjects already immunized with any vaccine within 4 weeks prior and expect to receive other vaccines within 60 days following the first dose 11. individuals who have a previously ascertained covid-19 in the period of 3 months before the first recruit of this study, or in a close contact in the last 14 days with confirmed case of covid-19 12. positive test for sars-cov-2 (antigen or pcr) at screening prior to first vaccination. testing may be repeated during the screening period if exposure to positive confirmed case of sars-cov-2 is suspected, at the discretion of investigator. 13. history of alcohol or substance abuse 14. hiv patients. 15. malignancy patients within 5 years prior to first study vaccination. 16. any neurological disease or history of significant neurological disorder such as meningitis, encephalitis, guillain-barre syndrome, multiple sclerosis, etc 17. vital sign abnormalities and clinical laboratory abnormalities as decided by the investigators. vital sign measurements and clinical laboratory testing may be repeated before the final decision. 18. women who are pregnant, breastfeeding, or who plan to become pregnant during the study. 19. participant has major psychiatric problem or illness 20. participant cannot communicate reliably with the investigator 21. participant has contraindication to intramuscular injection and blood draws, such as bleeding disorders or phobia. 22. participant had major surgery within 12 weeks before vaccination which will not be fully recovered, or has major surgery planned during the time participant is expected to participate in the study or within 6 months after the last dose of study vaccine administration. 23. any condition that in the opinion of the investigators would pose a health risk to the subject if enrolled or could interfere with the evaluation of the vaccine or interpretation of the study results 24. study team members. 25. subject planning to move from the study area before the end of study period.

1. subjects concomitantly enrolled or scheduled to be enrolled in another trial. 2. evolving mild, moderate, and severe illness, especially infectious diseases or fever (axillary temperature 37.5 degree celcius or more) concurrent or within 7 days prior to first study vaccination. this includes respiratory or constitutional symptoms consistent with sars-cov-2 (cough, sore throat, difficulty in breathing, etc) 3. known history of allergy to any component of the vaccines 4. history of uncontrolled coagulopathy or blood disorders contraindicating intramuscular injection 5. any autoimmune or immunodeficiency disease/condition 6. subjects who has received in the previous 4 weeks a treatment likely to alter the immune response (intravenous immunoglobulin, blood derived products, long term corticosteroid - more than 2 weeks, and so on), or anticipation of the need for immunosuppressive treatment within 6 months after last vaccination. the use of topical or nasal steroid will be permitted. inhaled glucocorticoids is prohibited. 7. chronic disease, inclusive of uncontrolled hypertension, congestive heart failure, chronic obstructive pulmonary disease, asthma, chronic urticaria, diabetes requiring use of medicine 8. any abnormality or chronic disease which according to the investigator might interfere with the assessment of the trial objectives 9. individuals who previously receive any vaccines against covid-19 10. subjects already immunized with any vaccine within 4 weeks prior and expect to receive other vaccines within 60 days following the first dose 11. individuals who have a previously ascertained covid-19 in the period of 3 months before the first recruit of this study, or in a close contact in the last 14 days with confirmed case of covid-19 12. positive test for sars-cov-2 (antigen or pcr) at screening prior to first vaccination. testing may be repeated during the screening period if exposure to positive confirmed case of sars-cov-2 is suspected, at the discretion of investigator. 13. history of alcohol or substance abuse 14. hiv patients. 15. malignancy patients within 5 years prior to first study vaccination. 16. any neurological disease or history of significant neurological disorder such as meningitis, encephalitis, guillain-barre syndrome, multiple sclerosis, etc 17. vital sign abnormalities and clinical laboratory abnormalities as decided by the investigators. vital sign measurements and clinical laboratory testing may be repeated before the final decision. 18. women who are pregnant, breastfeeding, or who plan to become pregnant during the study. 19. participant has major psychiatric problem or illness 20. participant cannot communicate reliably with the investigator 21. participant has contraindication to intramuscular injection and blood draws, such as bleeding disorders or phobia. 22. participant had major surgery within 12 weeks before vaccination which will not be fully recovered, or has major surgery planned during the time participant is expected to participate in the study or within 6 months after the last dose of study vaccine administration. 23. any condition that in the opinion of the investigators would pose a health risk to the subject if enrolled or could interfere with the evaluation of the vaccine or interpretation of the study results 24. study team members. 25. subject planning to move from the study area before the end of study period.

subjects concomitantly enrolled or scheduled to be enrolled in another trial. evolving mild, moderate, and severe illness, especially infectious diseases or fever (axillary temperature 37.5 degree celcius or more) concurrent or within 7 days prior to first study vaccination. this includes respiratory or constitutional symptoms consistent with sars-cov-2 (cough, sore throat, difficulty in breathing, etc) known history of allergy to any component of the vaccines history of uncontrolled coagulopathy or blood disorders contraindicating intramuscular injection any autoimmune or immunodeficiency disease/condition subjects who has received in the previous 4 weeks a treatment likely to alter the immune response (intravenous immunoglobulin, blood derived products, long term corticosteroid - more than 2 weeks, and so on), or anticipation of the need for immunosuppressive treatment within 6 months after last vaccination. the use of topical or nasal steroid will be permitted. inhaled glucocorticoids is prohibited. chronic disease, inclusive of uncontrolled hypertension, congestive heart failure, chronic obstructive pulmonary disease, asthma, chronic urticaria, diabetes requiring use of medicine any abnormality or chronic disease which according to the investigator might interfere with the assessment of the trial objectives individuals who previously receive any vaccines against covid-19 subjects already immunized with any vaccine within 4 weeks prior and expect to receive other vaccines within 60 days following the first dose individuals who have a previously ascertained covid-19 in the period of 3 months before the first recruit of this study, or in a close contact in the last 14 days with confirmed case of covid-19 positive test for sars-cov-2 (antigen or pcr) at screening prior to first vaccination. testing may be repeated during the screening period if exposure to positive confirmed case of sars-cov-2 is suspected, at the discretion of investigator. history of alcohol or substance abuse hiv patients. malignancy patients within 5 years prior to first study vaccination. any neurological disease or history of significant neurological disorder such as meningitis, encephalitis, guillain-barre syndrome, multiple sclerosis, etc vital sign abnormalities and clinical laboratory abnormalities as decided by the investigators. vital sign measurements and clinical laboratory testing may be repeated before the final decision. women who are pregnant, breastfeeding, or who plan to become pregnant during the study. participant has major psychiatric problem or illness participant cannot communicate reliably with the investigator participant has contraindication to intramuscular injection and blood draws, such as bleeding disorders or phobia. participant had major surgery within 12 weeks before vaccination which will not be fully recovered, or has major surgery planned during the time participant is expected to participate in the study or within 6 months after the last dose of study vaccine administration. any condition that in the opinion of the investigators would pose a health risk to the subject if enrolled or could interfere with the evaluation of the vaccine or interpretation of the study results study team members. subject planning to move from the study area before the end of study period.

subjects concomitantly enrolled or scheduled to be enrolled in another trial. evolving mild, moderate, and severe illness, especially infectious diseases or fever (axillary temperature 37.5 degree celcius or more) concurrent or within 7 days prior to first study vaccination. this includes respiratory or constitutional symptoms consistent with sars-cov-2 (cough, sore throat, difficulty in breathing, etc) known history of allergy to any component of the vaccines history of uncontrolled coagulopathy or blood disorders contraindicating intramuscular injection any autoimmune or immunodeficiency disease/condition subjects who has received in the previous 4 weeks a treatment likely to alter the immune response (intravenous immunoglobulin, blood derived products, long term corticosteroid - more than 2 weeks, and so on), or anticipation of the need for immunosuppressive treatment within 6 months after last vaccination. the use of topical or nasal steroid will be permitted. inhaled glucocorticoids is prohibited. chronic disease, inclusive of uncontrolled hypertension, congestive heart failure, chronic obstructive pulmonary disease, asthma, chronic urticaria, diabetes requiring use of medicine any abnormality or chronic disease which according to the investigator might interfere with the assessment of the trial objectives individuals who previously receive any vaccines against covid-19 subjects already immunized with any vaccine within 4 weeks prior and expect to receive other vaccines within 60 days following the first dose individuals who have a previously ascertained covid-19 in the period of 3 months before the first recruit of this study, or in a close contact in the last 14 days with confirmed case of covid-19 positive test for sars-cov-2 (antigen or pcr) at screening prior to first vaccination. testing may be repeated during the screening period if exposure to positive confirmed case of sars-cov-2 is suspected, at the discretion of investigator. history of alcohol or substance abuse hiv patients. malignancy patients within 5 years prior to first study vaccination. any neurological disease or history of significant neurological disorder such as meningitis, encephalitis, guillain-barre syndrome, multiple sclerosis, etc vital sign abnormalities and clinical laboratory abnormalities as decided by the investigators. vital sign measurements and clinical laboratory testing may be repeated before the final decision. women who are pregnant, breastfeeding, or who plan to become pregnant during the study. participant has major psychiatric problem or illness participant cannot communicate reliably with the investigator participant has contraindication to intramuscular injection and blood draws, such as bleeding disorders or phobia. participant had major surgery within 12 weeks before vaccination which will not be fully recovered, or has major surgery planned during the time participant is expected to participate in the study or within 6 months after the last dose of study vaccine administration. any condition that in the opinion of the investigators would pose a health risk to the subject if enrolled or could interfere with the evaluation of the vaccine or interpretation of the study results study team members. subject planning to move from the study area before the end of study period.