1. the patient's desire to discontinue participation in the study (withdrawal of informed consent). 2. the decision of the investigating physician that the patient should be excluded for the benefit of the patient him/herself; 3. the patient refuses to cooperate with the investigator or is not disciplined; 4. death of the patient; 5. progressing of the disease to a severe degree.

1. the patient's desire to discontinue participation in the study (withdrawal of informed consent). 2. the decision of the investigating physician that the patient should be excluded for the benefit of the patient him/herself; 3. the patient refuses to cooperate with the investigator or is not disciplined; 4. death of the patient; 5. progressing of the disease to a severe degree.

the patient's desire to discontinue participation in the study (withdrawal of informed consent). the decision of the investigating physician that the patient should be excluded for the benefit of the patient him/herself; the patient refuses to cooperate with the investigator or is not disciplined; death of the patient; progressing of the disease to a severe degree.

the patient's desire to discontinue participation in the study (withdrawal of informed consent). the decision of the investigating physician that the patient should be excluded for the benefit of the patient him/herself; the patient refuses to cooperate with the investigator or is not disciplined; death of the patient; progressing of the disease to a severe degree.