inclusion criteria: * age between 18 and 75 years * male or female * sars-cov-2 infection indicated by confirmed rt-pcr test * moderate hospitalized covid-19 (at least two out of three criterias below): * evidence of lower respiratory disease during clinical assessment (cough, fever, difficulty breathing) or imaging (x-rays) * oxygen saturation (spo2) in room air \< 93% * \<30 breaths per minute * no signs of hemodynamic decompensation * absence of pregnancy in women of childbearing age * ability to understand and comply with the requirements of the protocol * consent to participate * consent to use at least one highly effective contraception methods (condoms, iud, oral contraceptives) since the icf signature and at least 30 days after the study.

inclusion criteria: * age between 18 and 75 years * male or female * sars-cov-2 infection indicated by confirmed rt-pcr test * moderate hospitalized covid-19 (at least two out of three criterias below): * evidence of lower respiratory disease during clinical assessment (cough, fever, difficulty breathing) or imaging (x-rays) * oxygen saturation (spo2) in room air \< 93% * \<30 breaths per minute * no signs of hemodynamic decompensation * absence of pregnancy in women of childbearing age * ability to understand and comply with the requirements of the protocol * consent to participate * consent to use at least one highly effective contraception methods (condoms, iud, oral contraceptives) since the icf signature and at least 30 days after the study.

inclusion criteria: age between 18 and 75 years male or female sars-cov-2 infection indicated by confirmed rt-pcr test moderate hospitalized covid-19 (at least two out of three criterias below): evidence of lower respiratory disease during clinical assessment (cough, fever, difficulty breathing) or imaging (x-rays) oxygen saturation (spo2) in room air < 93% <30 breaths per minute no signs of hemodynamic decompensation absence of pregnancy in women of childbearing age ability to understand and comply with the requirements of the protocol consent to participate consent to use at least one highly effective contraception methods (condoms, iud, oral contraceptives) since the icf signature and at least 30 days after the study.

inclusion criteria: age between 18 and 75 years male or female sars-cov-2 infection indicated by confirmed rt-pcr test moderate hospitalized covid-19 (at least two out of three criterias below): evidence of lower respiratory disease during clinical assessment (cough, fever, difficulty breathing) or imaging (x-rays) oxygen saturation (spo2) in room air < 93% <30 breaths per minute no signs of hemodynamic decompensation absence of pregnancy in women of childbearing age ability to understand and comply with the requirements of the protocol consent to participate consent to use at least one highly effective contraception methods (condoms, iud, oral contraceptives) since the icf signature and at least 30 days after the study.