Created at Source Raw Value Validated value
June 25, 2024, noon usa

* history of olfactory dysfunction prior to covid-19 infection * any use of concomitant therapies specifically for the treatment of olfactory dysfunction * history of olfactory dysfunction of longer than 12 months * history of bipolar disorder as ssris can theoretically destabilize bipolar disorder * participants with symptoms of depression as evidenced by a score of 10 or greater on the patient health questionnaire-9 (phq-9).95 the phq-9 is a nine-item questionnaire designed to assess and aid in diagnosing patients with depression in clinical and community settings. * history of neurodegenerative disease (i.e., alzheimer's dementia, parkinson's disease, lewy body dementia, frontotemporal dementia) * history of chronic rhinosinusitis or sinus surgery * pregnant or breastfeeding mothers. * already enrolled in another covid 19 medication trial or receipt of monoclonal antibody infusion. * taking donepezil or fluoxetine (rationale: these drugs are s1r agonists) or sertraline (a s1r antagonist). * participants taking theophylline, tizanidine, clozapine, or olanzapine (drugs with a narrow therapeutic index that are primarily metabolized by cyp 1a2, which is inhibited by fluvoxamine. * taking another ssri, unless at a low dose (e.g., escitalopram 5mg) such that adding fluvoxamine would not put patient at risk for serotonin syndrome. * taking coumadin based on theoretical risk of increased bleeding with fluvoxamine. * unable to provide informed consent. * unable to perform the study procedures.

* history of olfactory dysfunction prior to covid-19 infection * any use of concomitant therapies specifically for the treatment of olfactory dysfunction * history of olfactory dysfunction of longer than 12 months * history of bipolar disorder as ssris can theoretically destabilize bipolar disorder * participants with symptoms of depression as evidenced by a score of 10 or greater on the patient health questionnaire-9 (phq-9).95 the phq-9 is a nine-item questionnaire designed to assess and aid in diagnosing patients with depression in clinical and community settings. * history of neurodegenerative disease (i.e., alzheimer's dementia, parkinson's disease, lewy body dementia, frontotemporal dementia) * history of chronic rhinosinusitis or sinus surgery * pregnant or breastfeeding mothers. * already enrolled in another covid 19 medication trial or receipt of monoclonal antibody infusion. * taking donepezil or fluoxetine (rationale: these drugs are s1r agonists) or sertraline (a s1r antagonist). * participants taking theophylline, tizanidine, clozapine, or olanzapine (drugs with a narrow therapeutic index that are primarily metabolized by cyp 1a2, which is inhibited by fluvoxamine. * taking another ssri, unless at a low dose (e.g., escitalopram 5mg) such that adding fluvoxamine would not put patient at risk for serotonin syndrome. * taking coumadin based on theoretical risk of increased bleeding with fluvoxamine. * unable to provide informed consent. * unable to perform the study procedures.

Feb. 2, 2022, 1 p.m. usa

history of olfactory dysfunction prior to covid-19 infection any use of concomitant therapies specifically for the treatment of olfactory dysfunction history of olfactory dysfunction of longer than 12 months history of bipolar disorder as ssris can theoretically destabilize bipolar disorder participants with symptoms of depression as evidenced by a score of 10 or greater on the patient health questionnaire-9 (phq-9).95 the phq-9 is a nine-item questionnaire designed to assess and aid in diagnosing patients with depression in clinical and community settings. history of neurodegenerative disease (i.e., alzheimer's dementia, parkinson's disease, lewy body dementia, frontotemporal dementia) history of chronic rhinosinusitis or sinus surgery pregnant or breastfeeding mothers. already enrolled in another covid 19 medication trial or receipt of monoclonal antibody infusion. taking donepezil or fluoxetine (rationale: these drugs are s1r agonists) or sertraline (a s1r antagonist). participants taking theophylline, tizanidine, clozapine, or olanzapine (drugs with a narrow therapeutic index that are primarily metabolized by cyp 1a2, which is inhibited by fluvoxamine. taking another ssri, unless at a low dose (e.g., escitalopram 5mg) such that adding fluvoxamine would not put patient at risk for serotonin syndrome. taking coumadin based on theoretical risk of increased bleeding with fluvoxamine. unable to provide informed consent. unable to perform the study procedures.

history of olfactory dysfunction prior to covid-19 infection any use of concomitant therapies specifically for the treatment of olfactory dysfunction history of olfactory dysfunction of longer than 12 months history of bipolar disorder as ssris can theoretically destabilize bipolar disorder participants with symptoms of depression as evidenced by a score of 10 or greater on the patient health questionnaire-9 (phq-9).95 the phq-9 is a nine-item questionnaire designed to assess and aid in diagnosing patients with depression in clinical and community settings. history of neurodegenerative disease (i.e., alzheimer's dementia, parkinson's disease, lewy body dementia, frontotemporal dementia) history of chronic rhinosinusitis or sinus surgery pregnant or breastfeeding mothers. already enrolled in another covid 19 medication trial or receipt of monoclonal antibody infusion. taking donepezil or fluoxetine (rationale: these drugs are s1r agonists) or sertraline (a s1r antagonist). participants taking theophylline, tizanidine, clozapine, or olanzapine (drugs with a narrow therapeutic index that are primarily metabolized by cyp 1a2, which is inhibited by fluvoxamine. taking another ssri, unless at a low dose (e.g., escitalopram 5mg) such that adding fluvoxamine would not put patient at risk for serotonin syndrome. taking coumadin based on theoretical risk of increased bleeding with fluvoxamine. unable to provide informed consent. unable to perform the study procedures.