inclusion criteria: 1. confirmed infection with covid-19 positive rt-pcr tracheal aspirate prior to treatment 2. use of mechanical ventilation with or without ecmo 3. male or female ages \> 18 years 4. \< 14 days from symptom initiation to study enrolment and \< 7 days from intubation to study enrolment

inclusion criteria: 1. confirmed infection with covid-19 positive rt-pcr tracheal aspirate prior to treatment 2. use of mechanical ventilation with or without ecmo 3. male or female ages \> 18 years 4. \< 14 days from symptom initiation to study enrolment and \< 7 days from intubation to study enrolment

inclusion criteria: confirmed infection with covid-19 positive rt-pcr tracheal aspirate prior to treatment use of mechanical ventilation with or without ecmo male or female ages > 18 years < 14 days from symptom initiation to study enrolment and < 7 days from intubation to study enrolment

inclusion criteria: confirmed infection with covid-19 positive rt-pcr tracheal aspirate prior to treatment use of mechanical ventilation with or without ecmo male or female ages > 18 years < 14 days from symptom initiation to study enrolment and < 7 days from intubation to study enrolment

inclusion criteria: 1. confirmed infection with covid-19 positive rt-pcr tracheal aspirate prior to treatment 2. use of mechanical ventilation with or without ecmo 3. male or female ages > 18 years 4. < 14 days from symptom initiation to study enrolment and < 7 days from intubation to study enrolment

inclusion criteria: 1. confirmed infection with covid-19 positive rt-pcr tracheal aspirate prior to treatment 2. use of mechanical ventilation with or without ecmo 3. male or female ages > 18 years 4. < 14 days from symptom initiation to study enrolment and < 7 days from intubation to study enrolment