* pregnancy * known or suspected malignancy in the lower limbs * body mass index equal or greater than 35 kg/m2 * conditions preventing nmes treatment (e.g., deep vein thrombosis, skin lesions, rhabdomyolysis) * conditions preventing the outcome assessment (e.g., amputation or inability to transfer independently from bed to chair before hospital admission) * presence of an implanted cardiac pacemaker or defibrillator

* pregnancy * known or suspected malignancy in the lower limbs * body mass index equal or greater than 35 kg/m2 * conditions preventing nmes treatment (e.g., deep vein thrombosis, skin lesions, rhabdomyolysis) * conditions preventing the outcome assessment (e.g., amputation or inability to transfer independently from bed to chair before hospital admission) * presence of an implanted cardiac pacemaker or defibrillator

- pregnancy - known or suspected malignancy in the lower limbs - body mass index equal or greater than 35 kg/m2 - conditions preventing nmes treatment (e.g., deep vein thrombosis, skin lesions, rhabdomyolysis) - conditions preventing the outcome assessment (e.g., amputation or inability to transfer independently from bed to chair before hospital admission) - presence of an implanted cardiac pacemaker or defibrillator

- pregnancy - known or suspected malignancy in the lower limbs - body mass index equal or greater than 35 kg/m2 - conditions preventing nmes treatment (e.g., deep vein thrombosis, skin lesions, rhabdomyolysis) - conditions preventing the outcome assessment (e.g., amputation or inability to transfer independently from bed to chair before hospital admission) - presence of an implanted cardiac pacemaker or defibrillator