1. requires supplemental o2 \>10 litres per minute or mechanical ventilation on admission 2. pregnancy 3. ast/alt \> 5 times the upper limit normal 4. baseline prolonged qt 5. child-pugh score b or greater 6. esrd(end-stage renal disease) requiring dialysis 7. known allergy to medication component, 8. history of severe g6pd (glucose-6-phosphate dehydrogenase) 9. myasthenia gravis 10. porphyria 11. ongoing treatment for epilepsy 12. life expectancy \< 6 months, 13. patient lacks capacity to provide consent and does not have a surrogate decision maker. 14. retinal disease

1. requires supplemental o2 \>10 litres per minute or mechanical ventilation on admission 2. pregnancy 3. ast/alt \> 5 times the upper limit normal 4. baseline prolonged qt 5. child-pugh score b or greater 6. esrd(end-stage renal disease) requiring dialysis 7. known allergy to medication component, 8. history of severe g6pd (glucose-6-phosphate dehydrogenase) 9. myasthenia gravis 10. porphyria 11. ongoing treatment for epilepsy 12. life expectancy \< 6 months, 13. patient lacks capacity to provide consent and does not have a surrogate decision maker. 14. retinal disease

requires supplemental o2 >10 litres per minute or mechanical ventilation on admission pregnancy ast/alt > 5 times the upper limit normal baseline prolonged qt child-pugh score b or greater esrd(end-stage renal disease) requiring dialysis known allergy to medication component, history of severe g6pd (glucose-6-phosphate dehydrogenase) myasthenia gravis porphyria ongoing treatment for epilepsy life expectancy < 6 months, patient lacks capacity to provide consent and does not have a surrogate decision maker. retinal disease

requires supplemental o2 >10 litres per minute or mechanical ventilation on admission pregnancy ast/alt > 5 times the upper limit normal baseline prolonged qt child-pugh score b or greater esrd(end-stage renal disease) requiring dialysis known allergy to medication component, history of severe g6pd (glucose-6-phosphate dehydrogenase) myasthenia gravis porphyria ongoing treatment for epilepsy life expectancy < 6 months, patient lacks capacity to provide consent and does not have a surrogate decision maker. retinal disease

1. requires supplemental o2 >10 litres per minute or mechanical ventilation on admission 2. pregnancy 3. ast/alt > 5 times the upper limit normal 4. baseline prolonged qt 5. child-pugh score b or greater 6. esrd(end-stage renal disease) requiring dialysis 7. known allergy to medication component, 8. history of severe g6pd (glucose-6-phosphate dehydrogenase) 9. myasthenia gravis 10. porphyria 11. ongoing treatment for epilepsy 12. life expectancy < 6 months, 13. patient lacks capacity to provide consent and does not have a surrogate decision maker. 14. retinal disease

1. requires supplemental o2 >10 litres per minute or mechanical ventilation on admission 2. pregnancy 3. ast/alt > 5 times the upper limit normal 4. baseline prolonged qt 5. child-pugh score b or greater 6. esrd(end-stage renal disease) requiring dialysis 7. known allergy to medication component, 8. history of severe g6pd (glucose-6-phosphate dehydrogenase) 9. myasthenia gravis 10. porphyria 11. ongoing treatment for epilepsy 12. life expectancy < 6 months, 13. patient lacks capacity to provide consent and does not have a surrogate decision maker. 14. retinal disease