* pregnancy and breastfeeding * foreseen inability to attend scheduled visits * history of acute coronary syndrome. coronary artery disease will be excluded by a clinical history, examination and electrocardiogram. * moderate or severe valve disease * primary cardiomyopathies * chronic obstructive pulmonary disease * asthma * chronic kidney disease (estimated glomerular filtration rate \[egfr\] ≤60 ml/min/1.73 m2) * liver failure * malignancies

* pregnancy and breastfeeding * foreseen inability to attend scheduled visits * history of acute coronary syndrome. coronary artery disease will be excluded by a clinical history, examination and electrocardiogram. * moderate or severe valve disease * primary cardiomyopathies * chronic obstructive pulmonary disease * asthma * chronic kidney disease (estimated glomerular filtration rate \[egfr\] ≤60 ml/min/1.73 m2) * liver failure * malignancies

pregnancy and breastfeeding foreseen inability to attend scheduled visits history of acute coronary syndrome. coronary artery disease will be excluded by a clinical history, examination and electrocardiogram. moderate or severe valve disease primary cardiomyopathies chronic obstructive pulmonary disease asthma chronic kidney disease (estimated glomerular filtration rate [egfr] ≤60 ml/min/1.73 m2) liver failure malignancies

pregnancy and breastfeeding foreseen inability to attend scheduled visits history of acute coronary syndrome. coronary artery disease will be excluded by a clinical history, examination and electrocardiogram. moderate or severe valve disease primary cardiomyopathies chronic obstructive pulmonary disease asthma chronic kidney disease (estimated glomerular filtration rate [egfr] ≤60 ml/min/1.73 m2) liver failure malignancies