1. do not intubate order; 2. pao2/fio2 ≤75 recorded at the time of consent. the pao2/fio2 can be imputed from pulse oximetry; 3. receiving imv via endotracheal intubation or tracheostomy; 4. receiving ecmo; 5. shock defined by the use of vasopressors; 6. known history of: * organ or hematologic transplant; * hiv; * active hepatitis b, or hepatitis c infection; 7. current treatment with: * chemotherapy; * immunosuppressive medications or immunotherapy (see protocol (section 5.3) for list of prohibited immunosuppressive medications and immunotherapy) at the time of consent; * hemodialysis or peritoneal dialysis; 8. known to be pregnant or is nursing; 9. currently participating in another study of an investigational drug or therapeutic medical device at the time of consent; 10. known allergy to eggs or any of the excipients in study drug.

1. do not intubate order; 2. pao2/fio2 ≤75 recorded at the time of consent. the pao2/fio2 can be imputed from pulse oximetry; 3. receiving imv via endotracheal intubation or tracheostomy; 4. receiving ecmo; 5. shock defined by the use of vasopressors; 6. known history of: * organ or hematologic transplant; * hiv; * active hepatitis b, or hepatitis c infection; 7. current treatment with: * chemotherapy; * immunosuppressive medications or immunotherapy (see protocol (section 5.3) for list of prohibited immunosuppressive medications and immunotherapy) at the time of consent; * hemodialysis or peritoneal dialysis; 8. known to be pregnant or is nursing; 9. currently participating in another study of an investigational drug or therapeutic medical device at the time of consent; 10. known allergy to eggs or any of the excipients in study drug.

do not intubate order; pao2/fio2 ≤75 recorded at the time of consent. the pao2/fio2 can be imputed from pulse oximetry; receiving imv via endotracheal intubation or tracheostomy; receiving ecmo; shock defined by the use of vasopressors; known history of: organ or hematologic transplant; hiv; active hepatitis b, or hepatitis c infection; current treatment with: chemotherapy; immunosuppressive medications or immunotherapy (see protocol (section 5.3) for list of prohibited immunosuppressive medications and immunotherapy) at the time of consent; hemodialysis or peritoneal dialysis; known to be pregnant or is nursing; currently participating in another study of an investigational drug or therapeutic medical device at the time of consent; known allergy to eggs or any of the excipients in study drug.

do not intubate order; pao2/fio2 ≤75 recorded at the time of consent. the pao2/fio2 can be imputed from pulse oximetry; receiving imv via endotracheal intubation or tracheostomy; receiving ecmo; shock defined by the use of vasopressors; known history of: organ or hematologic transplant; hiv; active hepatitis b, or hepatitis c infection; current treatment with: chemotherapy; immunosuppressive medications or immunotherapy (see protocol (section 5.3) for list of prohibited immunosuppressive medications and immunotherapy) at the time of consent; hemodialysis or peritoneal dialysis; known to be pregnant or is nursing; currently participating in another study of an investigational drug or therapeutic medical device at the time of consent; known allergy to eggs or any of the excipients in study drug.