1. patients refuse to enrol in the study 2. patients with hypersensitivity to colchicine 3. patients with chronic diseases: renal failure with egfr\<30 ml/min; chronic liver disease with hepatic failure (ast/alt \> 3x normal).; decompensated heart failure, long qt syndrome (qtc \>450 msec.), and uncontrolled arrhythmia; inflammatory bowel disease, chronic diarrhea or malabsorption; pre-existent progressive neuromuscular disease, and metastatic cancer 4. pregnancy and breast feeding 5. medications: immunosuppressive chemotherapy; regular use of digoxin, amiodarone, verapamil or protease inhibitors.

1. patients refuse to enrol in the study 2. patients with hypersensitivity to colchicine 3. patients with chronic diseases: renal failure with egfr\<30 ml/min; chronic liver disease with hepatic failure (ast/alt \> 3x normal).; decompensated heart failure, long qt syndrome (qtc \>450 msec.), and uncontrolled arrhythmia; inflammatory bowel disease, chronic diarrhea or malabsorption; pre-existent progressive neuromuscular disease, and metastatic cancer 4. pregnancy and breast feeding 5. medications: immunosuppressive chemotherapy; regular use of digoxin, amiodarone, verapamil or protease inhibitors.

patients refuse to enrol in the study patients with hypersensitivity to colchicine patients with chronic diseases: renal failure with egfr<30 ml/min; chronic liver disease with hepatic failure (ast/alt > 3x normal).; decompensated heart failure, long qt syndrome (qtc >450 msec.), and uncontrolled arrhythmia; inflammatory bowel disease, chronic diarrhea or malabsorption; pre-existent progressive neuromuscular disease, and metastatic cancer pregnancy and breast feeding medications: immunosuppressive chemotherapy; regular use of digoxin, amiodarone, verapamil or protease inhibitors.

patients refuse to enrol in the study patients with hypersensitivity to colchicine patients with chronic diseases: renal failure with egfr<30 ml/min; chronic liver disease with hepatic failure (ast/alt > 3x normal).; decompensated heart failure, long qt syndrome (qtc >450 msec.), and uncontrolled arrhythmia; inflammatory bowel disease, chronic diarrhea or malabsorption; pre-existent progressive neuromuscular disease, and metastatic cancer pregnancy and breast feeding medications: immunosuppressive chemotherapy; regular use of digoxin, amiodarone, verapamil or protease inhibitors.